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    Envigo offers a large collection of pre-developed genetically engineered ADME/Tox rat models including advanced disease research rat models including drug metabolism and transport and xenobiotic senor models to name a few. Envigo is a leader in molecular and phenotypic services featuring extensive scientific expertise in customized study and assay design, numerous in life and end point measurements, and study flexibility with comprehensive scientific project management.

    We are consistently and reliably available to partner with you on a scientific and personal level to design, execute, and deliver exactly what you need to achieve and exceed your research and development goals.

     

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    Genetically engineered models (GEMs)

    Rat Model Specific Disease/Biological Function Therapeutic Area
    Bcrp KO
    BSEP KO
    CAR KO
    Mdr1a KO
    Mdr1a/1b KO
    Mdr1a-Bcrp KO
    Mrp1 KO
    Mrp2 KO
    Oat1 KO
    Oat3 KO
    Oct1 KO
    Oct2 KO
    Drug metabolism, Transporter ADMET
    Ppara KO Diabetes, Drug metabolism, Obesity, Xenobiotic ADMET, Immunology
    PXR KO
    PXR/CAR KO
    PXR/CAR/AHR KO
    Drug metabolism, Xenobiotic ADMET
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