Mrp2 knockout rats: HsdSage:SD-Abcc2em1Sage GEM rats

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Mrp2 knockout rats

HsdSage:SD-Abcc2^em1Sage

Strain

HsdSage:SD-Abcc2^em1Sage

Location

U.S. (Cryopreserved)

Strain

Location

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Cryopreserved as heterozygous embryos

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background strain: Sprague Dawley
Biallelic 726 bp deletion within Abcc2 gene
Decreased transport of endogenous glutathione
Homozygous knockout rats display total loss of protein via Western blot
Hyperbilirubinemia

Availability: Cryopreserved as heterozygous embryos
Zygosity: Homozygous

Homozygous Mrp2 null rats display compromised biliary excretion and hyperbilirubinemia. This results in accumulation of glutathione-conjugated drugs in the liver.

Mrp2 is expressed in the liver and functions in biliary transport. The gene's substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells. This model is useful for forumational, efficacy, tissue distribution, and DMPK assays

Origin: The Mrp2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

United States - Room 12 - Boyertown

mrp2_figure2-01

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Model information sheet

Research use and related publications

ADMET
Tissue distribution
DMPKPK/PDFormulation
Drug transporter
Dubin-Johnson syndrome
Efficacy Drug-drug interactions
Efflux assays
Tissue distribution

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