PXR/CAR/AHR knockout rats: HsdSage:SD-NR1i2/NR1i3/AHRem1Sage GEM rats

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PXR/CAR/AHR knockout rats

HsdSage:SD-NR1i2/NR1i3/AHR^em1Sage

Strain

HsdSage:SD-NR1i2/NR1i3/AHR^em1Sage

Location

U.S. (Cryopreserved)

Strain

Location

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Cryopreserved as heterozygous embryos

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Biallelic 20 bp deletion within Nr1i2 gene
Biallelic 10 bp deletion within Nr1i3 gene
Biallelic 760 bp deletion within Ahr gene
Background Strain: Sprague-Dawley

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

PXR, CAR, and AHR are involved in the induction of cytochrome p4503A (Cyp3a) and are abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.

This triple knockout model was generated by crossing together the three single PXR, Car, and AHR knockout rat lines.

Origin:

The PXR/CAR/AHR Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

For pricing please contact us using the phone number above

Model information sheet

Research use and related publications

ADMET
Cholestasis
Cytochrome p450 pathways
Drug metabolism
Hepatotoxicity
Xenobiotic

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