• Background strain: Sprague Dawley
• Homozygous knockout rats display total loss of protein via Western blot

Availability: Live colony
Zygosity: Homozygous

This model contains a bi-allelic deletion within the peroxisome proliferator-activated receptor alpha gene (Ppara).

Ppara (peroxisome proliferator-activated receptor alpha gene) is a ligand activated nuclear receptor, known to be activated by free fatty acids and their derivatives. Besides the studying of lipid metabolism and diabetes, Ppar-alpha affect the expression of target genes involved in cell proliferation, cell differentiation, and in immune and inflammation responses.