• Background strain: Sprague Dawley
• Decreased transport of glutatione-conjugated substrates
• Homozygous knockout rats display total loss of protein via Western blot
• Increased bioavailability of specific substrate Fluorescein

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

This model contains a 43 base pair bi-allelic deletion within the Mrp1 gene, synonym Abcc1a (ATP-binding cassette, sub-family C [CFTR/MRP], member 1a), encoding an ATP-dependent drug transporter.

Mrp1 is a multispecific organic anion transporter that extrudes glutathione-, glucouronide- or sulfate-conjugated substrates (steroids, leukotrienes, etc.), as well as xenobiotic drugs out of cells. Mrp1 can confer multiple drug resistance to tumor cells. Absence of Mrp1 creates a functional deficiency in the cellular transport of some substrates and results in compromised inflammatory response, making this model useful for studying drug transport in inflammatory stimulus response and chemotherapeutic agents.