Oat3 knockout rats: HsdSage:SD-Slc22a8em1Sage GEM rats

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Oat3 knockout rats

HsdSage:SD-Slc22a8^em1Sage

Strain

HsdSage:SD-Slc22a8^em1Sage

Location

U.S. (Cryopreserved)

Strain

Location

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Cryopreserved as heterozygous embryos

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

This model contains a biallelic deletion of the organic anion transporter 3 (Oat3), also known as solute carrier family 22 member 8 (SLC22A8). Oat3 plays a central role in renal organic anion transport. Along with Oat1, Oat3 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys- making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver.

Origin:

The Oat3 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Model information sheet

Research use and related publications

ADMET
Drug-drug interactions
Drug metabolism
Drug transporter
Hepatotoxicity

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