The B-NDG model is a single knockout mouse with an ultra immunodeficient phenotype. The model was generated by Biocytogen by deleting the IL2rg gene from NOD-scid mice.
Prkdc (protein kinase DNA-activated catalytic) null scid mutation is characterized by significantly deficient of functional T cells and B cells.
The Common gamma chain gene (IL2RG) deletion results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, which results in the lack of functional NK cells.
Envigo licensed the mouse model from Biocytogen in 2019, where the model had been maintained. The model is albino.