129 inbred mice 129S2/SvHsd Inbred mice Production of targeted mutations due to the availability of several lines of embryonic stem cells~Ovary transplant and ova transfer studies 129S2 Coat: Black-eyed, light-bellied agouti High incidence of testicular teratomas High incidence of urinary calculi Histocompatibility: H-1b, H-2b, H-3b Low blood pressure Low overall tumor incidence --
Research use:
Production of targeted mutations due to the availability of several lines of embryonic stem cells, Ovary transplant and ova transfer studies
5Ht3a-Cre knockin rats HsdSage:LE-5HT3atm1(T2A-Cre)Sage GEM rats Optogenetics~Expression/knockout of floxed genes Background strain: Long Evans Hooded Cre recombinase driven by endogenous 5Ht3a promoter No observed ectopic expression of cre Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC Availability: Live colony Zygosity genotype: Homozygous This model expresses cre-recombinase under the control of the endogenous 5’- hydroxytryptamine receptor 3A (5Ht3a) promoter enabling specific expression in 5Ht3a positive serotonergic neurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the 5Ht3a gene. The 5Ht3a-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. --
Research use:
Optogenetics, Expression/knockout of floxed genes
A inbred mice A/JOlaHsd Inbred mice General studies~Behavior~Teratogenesis~Carcinogenesis Coat: Albino Defect in macrophage function Genetics: H2a, H-1, H-3, Lshr (Leishmania donovani infection), C5 Complement Deficient (Hco)1, Qo2a, Lsr1s High incidence of spontaneous and chemically-induced lung adenomas High susceptibility to cortisone-induced congenital cleft palate Litter Average 4.4 --
Produced in:
U.S., U.K., The Netherlands
Research use:
General studies, Behavior, Teratogenesis, Carcinogenesis
ACI inbred rats ACI/SegHsd Inbred rats Carcinogenesis~Estrogen-induced pituitary growth~Transplant immunology Coat: Black Agouti, with white belly and feet Haplotype: RT1av1 High incidence of congenital malformations including renal agenesis, hypoplasia, hydronephrosis or cystic kidney, unilateral, that may be associated with ipsilateral defective uterine horn or testis High incidence of testicular tumors Litter average: 6.0 Poor reproductive performance and low litter size due to high in-utero mortality --
Research use:
Carcinogenesis, Estrogen-induced pituitary growth, Transplant immunology
AHR knockout rats HsdSage:SD-Ahrtm1Sage GEM rats Xenobiotic sensor~Cytochrome p450 pathways~Drug metabolism~Cholestasis~Hepatotoxicity Background strain: Sprague Dawley Biallelic deletion of Ahr Availability: Live colony Zygosity: Homozygous AHR is involved in the induction of cytochrome p450s and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity. --
Research use:
ADMET, Xenobiotic sensor, Cytochrome p450 pathways, Drug metabolism, Cholestasis, Hepatotoxicity
Alpha-Synuclein A53T SNCA knockin rats HsdSage:SD-SNCAtm1(SNCA-A53T)Sage GEM rats Parkinson's disease~Dopaminergic cell toxicity Background strain: Sprague Dawley Availability: Live colony Zygosity genotype: Homozygous Developed in collaboration with The Michael J. Fox Foundation, this model contains a knockin of the A53T-mutated SNCA gene deeming the rat SNCA gene non-functional. The knockin contains humanized amino acids for the region spanning amino acids 53-122. The resulting model expresses a humanized A53T alpha-synuclein protein without endogenous rat alpha-synuclein. This model was generated using CRISPR/Cas9 genome targeting strategies. The A53T mutation in the SNCA gene has been linked to early-onset Parkinson’s disease (PD), making this model useful for understanding alpha-synuclein biology and PD pathogenesis. --
Research use:
Parkinson's disease, Dopaminergic cell toxicity
Alpha-Synuclein-SNCA knockout rats HsdSage:SD-SCNAtm1Sage GEM rats Parkinson's disease~Dopaminergic cell toxicity Background strain: Sprague Dawley Availability: Live colony Zygosity genotype: Homozygous Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the endogenous rat SNCA gene, encoding the alpha-synuclein protein. This model was generated using the CRISPR/Cas9 genome targeting strategy. Mutations and multiplications of the SNCA gene have been linked to early-onset Parkinson’s disease (PD), making this model useful for understanding alpha-synuclein biology and PD pathogenesis. --
Research use:
Parkinson's disease, Dopaminergic cell toxicity
ApoE knockout rats HsdSage:SD-ApoEtm1Sage GEM rats Alzheimer's disease~Neurodegenerative diseases 16 bp deletion within Exon 3 on chromosome 1 Administration of high fat diets to ApoE KO rats has resulted in significantly reduced lifespan (Envigo does not recommend administering high fat diets to ApoE KO rats) At an early age (5- and 10-week-old), ApoE knockouts demonstrate significantly higher serum cholesterol Background strain: Sprague Dawley Homozygous knockouts exhibit complete loss of ApoE protein via Western blot Availability: Live colony Zygosity genotype: Homozygous Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood. ApoE is essential for the normal metabolism of lipids. It is expressed in the liver, intestines and brain, preventing the accumulation of cholesterol-rich particles in plasma. Widely studied for its role in cardiovascular disease and lipoprotein transport, it has more recently been implicated in Alzheimer's disease and cognition, making this a useful model for the study of atherosclerosis, Alzheimer's and nerve injury. --
Research use:
Neuroscience, Alzheimer's disease, Neurodegenerative diseases
App knockout rats HsdSage:SD-Apptm1Sage GEM rats Alzheimer's disease~Neurodegeneration~Memory loss~Dementia~Synaptic formation and repair Homozygous knockout rats exhibit complete loss of protein Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model carries a bi-allelic deletion of the amyloid precursor protein (APP) gene. APP can be cleaved by the beta and gamma secretases, forming beta amyloid. Beta amyloid can self-aggregate to form amyloid plaques, one of the hallmarks of Alzheimer's disease. --
Produced in:
U.S.
Cryopreserved
Research use:
Alzheimer's disease, Neurodegeneration, Memory loss, Dementia, Synaptic formation and repair
Athymic nude mice Hsd:Athymic Nude-Foxn1nu Mutant mice Sentinel model - Heterozygous Hsd:Athymic Nude-Foxn1nu/Foxn1+ B-cells function normal Coat: Albino Dysfunctional rudimentary thymus Foxn1nu/Foxn1+ heterogygotes do not show partial expression of the nu phenotype Litter Average: 7 No generation of cytotoxic effector cells No graft versus host response Phenotypically hairless (sparse, intermittent hair growth possible) T-cell deficient The nu allele on chromosome 11 is an autosomal recessive mutation --
Produced in:
U.S., U.K., Israel, France
Research use:
Immunology, Oncology, Transplantation, General studies, Antibody production, Autoimmune disease, Tumor growth, Gene Therapy, Sentinel model - Heterozygous Hsd:Athymic Nude-Foxn1nu/Foxn1+
Athymic nude rats Hsd:RH-Foxn1rnu Mutant rats Coat: Hooded (pigmented) Foxn1rnu/Foxn1+ heterozygotes do not show partial expression of rnu phenotype Increased Natural Killer (NK) cell population Phenotypically hairless (sparse hair growth possible) Rudimentary thymic tissue The rnu allele on chromosome 10 is an autosomal recessive mutation associated with hairlessness and thymic aplasia The thymus-dependent lymph node areas are depleted of lymphocytes (T-cells) --
Produced in:
U.S., France
Research use:
Immunology, Oncology, Transplantation, General studies,
Athymic nude mice Hsd:Athymic Nude-Foxn1nu/Foxn1+ Mutant mice Sentinel model - Heterozygous Hsd:Athymic Nude-Foxn1nu/Foxn1+ B-cells function normal Coat: Albino Dysfunctional rudimentary thymus Foxn1nu/Foxn1+ heterogygotes do not show partial expression of the nu phenotype Litter Average: 7 No generation of cytotoxic effector cells No graft versus host response Phenotypically hairless (sparse, intermittent hair growth possible) T-cell deficient The nu allele on chromosome 11 is an autosomal recessive mutation --
Produced in:
U.S., U.K., Israel, France
Research use:
Immunology, Oncology, Transplantation, General studies, Antibody production, Autoimmune disease, Tumor growth, Gene Therapy, Sentinel model - Heterozygous Hsd:Athymic Nude-Foxn1nu/Foxn1+
B-NDG knockout mice NOD.CB17-Prkdcscid IL2rgtm1/BcgenHsd GEM mice Infectious disease~Humanization applications Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16 Coat: Albino Common gamma chain gene (II2rg) interrupted Deficiency in cytokine signaling Deficient in T and B cells High humanization capability Lacks functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 Lacks NK cells Severe lymphocyte development impairment --
Research use:
Oncology, Chemoresistance, Stem Cells, Immunotherapy, Tumor growth, Infectious disease, Humanization applications
B6C3F1 hybrid mice B6C3F1/Hsd Hybrid mice Toxicology~Carcinogenicity~Embryo donors Coat: Agouti Haplotype: H-2b/k Litter Average: 7 Will accept transplanted tissues from either parent strain --
Produced in:
U.S., The Netherlands
Research use:
Toxicology, Carcinogenicity, Embryo donors
B6CBAF1 hybrid mice B6CBAF1/OlaHsd Hybrid mice Coat: Agouti Litter Average 6.7 Will accept transplanted tissues from either parent --
B6D2F1 hybrid mice B6D2F1/Hsd Hybrid mice Behavior~ Tumorigenicity~ Bioassay of nutrients, drugs, and hormones --
Produced in:
U.S., The Netherlands, Israel
Research use:
, Behavior, Tumorigenicity, Bioassay of nutrients, drugs, and hormones
BALB/c inbred mice BALB/cAnNHsd Inbred mice General purpose Coat: Albino Docile disposition Experimental allergic encephalomyelitis resistant Haplotype: H-2d Litter average: 6.0 --
Produced in:
U.S., U.K., The Netherlands, Israel
Research use:
Oncology, Toxicology, Transplantation, Aging, General studies, Teratology, Antibody production, Cardiovascular, Pharmacology, General purpose
BALB/c nude mice BALB/cOlaHsd-Foxn1nu Mutant mice Autoimmune disease~Antibody production~Sentinel model - Heterozygous BALB/cOlaHsd-Foxn1nu/Foxn1+ B-cells function normal Coat: Albino Dysfunctional rudimentary thymus Foxn1nu/Foxn1+ heterogygotes do not show partial expression of the nu phenotype No generation of cytotoxic effector cells No graft versus host response Phenotypically hairless (sparse, intermittent hair growth possible) T-cell deficient The nu allele on chromosome 11 is an autosomal recessive mutation --
Produced in:
U.K., Israel, France
Research use:
Immunology, Oncology, Transplantation, Tumor growth, Imaging, Autoimmune disease, Antibody production, Sentinel model - Heterozygous BALB/cOlaHsd-Foxn1nu/Foxn1+
Bcrp knockout rats HsdSage:SD-Abcg2tm1Sage GEM rats DMPK efflux assay~Formulation blood brain barrier efflux~Drug-drug interactions~Tissue distribution~Efficacy assay Background strain: Sprague Dawley Biallelic 588 bp deletion within Abcg2 gene Homozygous knockouts display total loss of protein via Western blot Increased oral bioavailability of BCRP-specific substrates Availability: Live colony Zygosity genotype: Homozygous Bcrp plays a protective role in neurotoxicity by limiting the efflux of xenobiotics into the brain. Homozygous null rats demonstrate increased exposure in the brain and plasma when dosed with Bcrp-specific substrates. Loss of function of Bcrp leads to improper transport of drugs across epithelial cells and increased bioavailability of Bcrp substrates. This model is useful for studying metabolism of xenobiotic compounds, tissue distribution, DMPK, efficacy, formulation, and blood brain barrier efflux. --
Research use:
ADMET, DMPK efflux assay, Formulation blood brain barrier efflux, Drug-drug interactions, Tissue distribution, Efficacy assay
BDNF knockout rats HsdSage:SD-Bdnftm1Sage GEM rats Alzheimer's disease~Depression~Huntington's disease~Memory loss~Nerve growth and development~Pain~Post-traumatic stress disorder~Schizophrenia Background strain: Sprague Dawley Heterozygous Bdnf knockout rats (+/-) display lower total and peripheral activity, suggestive of reduced exploratory behavior Heterozygous Bdnf knockout rats (+/-) show decrease in freezing behavior in contextual fear conditioning assay, suggestive of emotional learning and memory deficits Homozygous knockout rats exhibit complete loss of BDNF protein and have a lifespan of 2-3 days Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a monoallelic deletion of the Bdnf gene, encoding for the nerve growth factor protein BDNF. Homozygous animals carrying the Bdnf deletion are postnatal lethal. Reductions of BDNF have been observed in patients with Alzheimer's disease (AD), and this model may be useful for understanding the role of BDNF in AD. Bdnf is one of the most active and essential of the neurotophins, contributing to the growth and differentiation of neurons in the hippocampus, cortex and forebrain. These areas are key for cognition, learning and memory. Deficiency in Bdnf levels have been linked to a host of neurological diseases, including Alzheimer's, depression, schizophrenia and dementia, making this an important model for studying the central nervous system. --
Produced in:
U.S.
Cryopreserved
Research use:
Neuroscience, Alzheimer's disease, Depression, Huntington's disease, Memory loss, Nerve growth and development, Pain, Post-traumatic stress disorder, Schizophrenia
HsdHre:Beagles HsdHre:Beagle Canine All of our models undergo our Bio Sensor Program for increased overall health Bacteriology, parasitology, blood chemistry and hematology External parasite control and prophylactic programs Properly socialized and acclimated so you can start your research immediately Thorough preventive health program from 5 weeks to 15 weeks of age For more information please contact us or check the technical resources section --
Research use:
Toxicology, Pharmacology, Cellular Therapies, Ocular Studies,
Brown Norway inbred rats BN/RijHsd Inbred rats Allergic Respiratory Disease~Nephrology~Leukemia Coat: Brown, non-agouti Haplotype: RT1n High incidence of bladder tumors in males Hyper-responsive lungs Litter average: 4.5 --
Produced in:
U.S., U.K., The Netherlands
Research use:
Oncology, Transplantation, Aging, General studies, Allergic Respiratory Disease, Nephrology, Leukemia
BSEP knockout rats HsdSage:SD-Abcb11tm1Sage GEM rats Drug-drug interactions~Cholestasis~Drug-induced cholestasis (DIC)~Transporter assays Background strain: Sprague Dawley Biallelic 8bp deletion within the Abcb11 gene Homozygous knockout rats display total loss of protein via Western blot Availability: Cryopreserved as heterozygous embryos Zygosity:Heterozygous Abcb11 encodes the bile salt export pump (BSEP) found in the liver. BSEP is critical in the secretion of bile by releasing bile salts from the liver, and mutations in BSEP have been associated with progressive familial intrahepatic cholestasis in humans. Drug induced liver injury is an important clinical issue, and may result from inhibition of BSEP. Chemical inhibition of BSEP can lead to decreased bile flow and buildup of bile salts in hepatocytes, resulting in toxicity. Understanding the potential of BSEP inhibition by drug candidates is thus of significant importance for drug discovery and development. This model is useful in studying impairment of bile secretion. --
Produced in:
U.S.
Cryopreserved
Research use:
ADMET, Drug-drug interactions, Cholestasis, Drug-induced cholestasis (DIC), Transporter assays
C3H inbred mice C3H/HeNHsd Inbred mice Immunology~General studies~Ocular disease Carrier of the retinal degeneration (Pde6brd1) mutation Coat: Agouti Haplotype: H-2k Highly susceptible to Anthrax toxin Litter Average 4.6 Normal response to LPS --
Produced in:
U.S., The Netherlands, Israel
Research use:
Immunology, General studies, Ocular disease
C57BL/6 aged inbred mice C57BL/6JRccHsd Aged Inbred mice Metabolism~Cardiovascular~Memory~Osteoarthritis~Neoplasia~Immune response~Longevity~Vision and hearing~Motor skills~Renal degeneration~Age-associated pathology~Neurobiology~Reproductive senescence Coat: Black Haplotype: H-2b High preference for alcohol Incidence of hydrocephalous Low tumor incidence Microphthalmia Most widely-used inbred strain The C57BL/6JRccHsd subline does not carry the Nnt (nicotinamide nucleotice transhydrogenase) gene deletion Common age-associated conditions include: Hair loss Loss of motor skills and sensory perception Presence of spontaneous tumors Reduced immunologic and physiologic function Loss of vision, e.g. retinal degeneration, development of cataracts --
Produced in:
The Netherlands
Research use:
Metabolism, Cardiovascular, Memory, Osteoarthritis, Neoplasia, Immune response, Longevity, Vision and hearing, Motor skills, Renal degeneration, Age-associated pathology, Neurobiology, Reproductive senescence
C57BL/6 albino mice C57BL/6BrdCrHsd-Tyrc Mutant mice Source of albino C57BL/6 embryos for chimera generation~Ovarian transfer Coat: Albino Contains a mutation in the c(tyrosinase) gene Haplotype: H-2b Litter Average: 6.5 --
Produced in:
U.S., U.K., France
Research use:
Source of albino C57BL/6 embryos for chimera generation, Ovarian transfer
C57BL/6 inbred mice C57BL/6JOlaHsd Inbred mice Background for induced and genetically-modified models~Diet-induced obesity~Superovulation~Behavior and learning disabilities~Drug addiction Coat: Black Haplotype: H-2b Litter Average: 5.0 Most widely-used inbred strain Low tumor incidence High preference for alcohol Microphthalmia Incidence of hydrocephalous The C57BL/6JOlaHsd subline carries a deletion at the alpha synuclien locus --
Produced in:
U.S., U.K., The Netherlands, Israel
Research use:
Immunology, Oncology, Toxicology, Aging, General studies, Behavior, Cardiovascular, Neuroscience, Genetically Modified, Alpha Synuclein, Alcoholism, Cardiovascular; DIO, Diet induced obesity, Background for induced and genetically-modified models, Diet-induced obesity, Superovulation, Behavior and learning disabilities, Drug addiction
C57BL/Ka inbred mice C57BL/KaLwRijHsd Inbred mice Coat: Black Haplotype: H-2b Litter Average: 5.0 --
Cacna1c knockout rats HsdSage:SD-Cacna1ctm1Sage GEM rats Alzheimer's disease~ Neurodegeneration~ Memory loss~ Dementia~ Synaptic formation and repair Background Strain:Sprague-dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a deletion of the 1c subunit of the L-type voltage-gated calcium channel CACNA1C. Cav1.2 is an L-type voltage-gated calcium channel encoded by the Cacna1c gene. Mutations in Cav1.2 result have been associated with schizophrenia, bipolar disorder, and most notably Timothy syndrome. Timothy syndrome is associated with long QT syndrome, heart arrhythmias, neurological impairment, and autism. --
Produced in:
U.S.
Cryopreserved
Research use:
, Alzheimer's disease, Neurodegeneration, Memory loss, Dementia, Synaptic formation and repair
CamKIIa-Cre knockin rats HsdSage:LE-CAMKIIAtm1(IRES-Cre)Sage GEM rats Optogenetics~Expression/knockout of floxed genes Background strain: Long Evans Hooded Cre recombinase driven by endogenous CamKIIa promoter No observed ectopic expression of cre Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC Availability: Live colony Zygosity genotype: Homozygous This model expresses cre-recombinase under the control of the endogenous camkIIa promoter enabling specific expression in excititory neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of CamkIIa. The CamkIIa-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. --
Research use:
Optogenetics, Expression/knockout of floxed genes
CAR knockout rats HsdSage:SD-NR1I3tm1Sage GEM rats Xenobiotic sensor~Cytochrome p450 pathways~Cholestasis~Hepatotoxicity~sDrug metabolism Background strain: Sprague Dawley Availability: Cryopreserved as homozygous embryos Zygosity: Homozygous CAR is involved in the induction of cytochrome p450s and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity. The activation of nuclear receptors, including the Pregnane X Receptor (PXR) and the Constitutive Androstane Receptor (CAR), is a common Mode of Action (MoA) for chemicals that exhibit non-genotoxic hepatocarcinogenicity in rodents. Conversely, the activation of the human PXR and/or CAR receptors is not believed to result in a carcinogenic response. Therefore, if a compound causes liver tumors in rodents, or if studies demonstrate that the compound is a nuclear receptor agonist, it is critical to unambiguously demonstrate the role of specific nuclear receptors in the rodent response, for example by using PXR or CAR KO rats. CXR has extensive experience of working with global pharmaceutical, chemical and agrochemical companies to demonstrate the absence of human relevance for nuclear-receptor mediated carcinogenicity. --
Produced in:
U.S.
Cryopreserved
Research use:
ADMET, Xenobiotic sensor, Cytochrome p450 pathways, Cholestasis, Hepatotoxicity, sDrug metabolism
CB6F1 hybrid mice CB6F1/Hsd Hybrid mice Immunology~Behavior~Infection~Reproductive Biology Coat: Agouti Haplotype: H-2b/d Litter Average 5.7 Will accept transplanted tissues from either parent strain --
Produced in:
U.S., The Netherlands, Israel
Research use:
Immunology, Behavior, Infection, Reproductive Biology
CBA inbred mice CBA/JCrHsd Inbred mice Immunology~General purpose~Only approved mouse strain for use in the Local Lymph Node Assay, a refined alternative research method for evaluating the allergic contact dermatitis potential of chemicals and compounds Carriers of the retinal degeneration (Pde6brd1) mutation Coat: Agouti Haplotype: H-2k Litter average: 4.0 Low incidence of mammary tumors in females Susceptible to radiation --
Research use:
Immunology, General purpose, Only approved mouse strain for use in the Local Lymph Node Assay, a refined alternative research method for evaluating the allergic contact dermatitis potential of chemicals and compounds
CBA/Ca inbred mice CBA/CaOlaHsd Inbred mice Coat: Agouti Haplotype: H-2k Litter Average: 5.0 --
CD1 nude mice HsdHli:CD1-Foxn1nu Mutant mice Immunology~Autoimmune disease~Antibody production B-cells function normal Coat: Albino Dysfunctional rudimentary thymus No generation of cytotoxic effector cells No graft versus host response Phenotypically hairless (sparse, intermittent hair growth possible) T-cell deficient The nu allele on chromosome 11 is an autosomal recessive mutation --
Research use:
Oncology, Transplantation, Tumor growth, Immunology, Autoimmune disease, Antibody production
CD2F1 hybrid mice CD2F1/Hsd Hybrid mice Carcinogenesis~Pharmacology Coat: Beige Will accept transplanted tissues from either parent strain; e.g.~ L1210 and P388 leukemia --
Research use:
Carcinogenesis, Pharmacology
CFTR knockout rats HsdSage:SD-Cftrtm1Sage GEM rats Chloride transport~Cystic Fibrosis~Thiocyanide transport Homozygotes exhibit multiple phenotypes involving intestinal, respiratory, and reproductive phenotypes (see Description). Availability: Cryopreserved as a mix of Heterozygous & WT embryos Zygosity: Heterozygous CFTR knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (CFTR), resulting in loss of protein expression. CFTR knockout rats lack CFTR protein as demonstrated by western blot. CFTR KO rats develop intestinal obstructions shortly after weaning leading to weight loss and mortality. CFTR KO rats also exhibit decreased trachea circumference as well as submucosal gland volume. Stored nasal mucus volume is increased. Abnormal dentition is observed, and the vas deferens is absent in male CFTR knockout rats. --
Produced in:
U.S.
Cryopreserved
Research use:
Lung Disease, Chloride transport, Cystic Fibrosis, Thiocyanide transport
CHD8 knockout rats HsdSage:SD-CHD8tm1Sage GEM rats Autism This model was created in collaboration with Autism Speaks 13 bp deletion in CHD8 Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Generated in conjunction with Autism Speaks, this knockout rat model possesses a 13 bp deletion in the chromodomain helicase DNA binding protein encoded by the CHD8 gene and is a chromatin regulator enzyme that is essential during fetal development. CHD8 has been associated with autism spectrum disorders. --
Produced in:
U.S.
Cryopreserved
Chrna7 knockout rats HsdSage:SD-Chrna7tm1Sage GEM rats Schizophrenia~ Epilepsy~ Neuronal growth and transport studies Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model is a biallelic deletion of the Chrna7 gene, part a family of ligand-gated ion channels that mediate fast signal transmission at synapses. Disruptions of this gene have been shown to be involved in juvenile myoclonic epilepsy and schizophrenia. --
Produced in:
U.S.
Cryopreserved
Research use:
Schizophrenia, Epilepsy, Neuronal growth and transport studies
Cntnap2 knockout rats HsdSage:SD-Cntnap2tm1Sage GEM rats Autism Spectrum Disorders~Cell adhesion~Language disorders~Synaptic Plasticity 5 base pair deletion in exon 6 of Cntnap2 Background strain: Sprague Dawley Homozygous knockout rats display total loss of protein via Western blot Spontaneous seizures >7 weeks of age This model was created in collaboration with Autism Speaks and underwent phenotypic characterization by Dr. Richard Paylor. Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Generated in conjunction with Autism Speaks, this model possesses a bi-allelic deletion in the contactin associated protein-like 2 (Cntnap2) gene. A member of the neurexin family, Cntnap2 has been associated with the autism spectrum disorders. Spontaneous seizures have been observed in homozygous animals >7 weeks of age. --
Produced in:
U.S.
Cryopreserved
Research use:
Neuroscience, Autism Spectrum Disorders, Cell adhesion, Language disorders, Synaptic Plasticity
Cotton rats Hsd:Cotton Rat Cotton rats Adenoviral vector-based gene therap~Herpes Simplex~Parainfluenza Type 3~Polio~Measles~Monkeypox~Human metapneumovirus~Mycobacterium tuberculosis Coat: color combination varies; gray, brown, black Litter average: 5.5 New World rodent: Sigmodon hispidus Susceptible to a wide range of human infectious disease agents --
Research use:
Infectious disease, Adenoviral vector-based gene therap, Herpes Simplex, Parainfluenza Type 3, Polio, Measles, Monkeypox, Human metapneumovirus, Mycobacterium tuberculosis
Cox1 knockout rats HsdSage:SD-Cox1tm1Sage GEM rats Rheumatoid arthritis~Inflammation/Autoimmune disorders~Asthma~Multiple sclerosis~Thrombosis/Cardiac fibrosis~Vascular defects~Platelet defects/Platelet aggregation~Renal dysplasia~Crohn's disease~Colitis Homozygous knockout rats exhibit complete loss of COX1 protein via Western blot Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Cyclooxygenase (COX), also known as prostaglandin synthase (PHS) and prostaglandin endoperoxide synthetase (PES), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Rats deficient in COX1 can be used for studying inflammation, thrombosis, vascular defects, platelet defects and alterations in platelet aggregation. --
Produced in:
U.S.
Cryopreserved
Research use:
Rheumatoid arthritis, Inflammation/Autoimmune disorders, Asthma, Multiple sclerosis, Thrombosis/Cardiac fibrosis, Vascular defects, Platelet defects/Platelet aggregation, Renal dysplasia, Crohn's disease, Colitis
Cox2 knockout rats HsdSage:SD-Cox2tm1Sage GEM rats Rheumatoid arthritis~Inflammation/Autoimmune disorders~Asthma~Multiple sclerosis~Thrombosis/Cardiac fibrosis~Vascular defects~Platelet defects/Platelet aggregation~Renal dysplasia~Crohn's disease~Colitis Homozygous knockouts display loss of COX2 protein via Western blot Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous COX2 is one of the isoenzymes from Cyclooxygenase (COX) family and is responsible for inflammation and pain. Several pain relieving drugs such as Celecoxib and Rofecoxib selectively target COX2. --
Produced in:
U.S.
Cryopreserved
Research use:
Rheumatoid arthritis, Inflammation/Autoimmune disorders, Asthma, Multiple sclerosis, Thrombosis/Cardiac fibrosis, Vascular defects, Platelet defects/Platelet aggregation, Renal dysplasia, Crohn's disease, Colitis
CrlHli:CD-1 outbred mice CrlHli:CD-1 Outbred mice Coat: Albino General purpose model --
CSJLF1 hybrid mice CSJLF1/HliHsd Hybrid mice Will accept transplanted tissues from either parent --
Cynomolgus macaques M. fascicularis Nonhuman primates Chinese, Vietnamese and Cambodian cynomolgus macaque holding facility in Alice, Texas Limited availability for sexually mature animals Mauritius cynomolgus macaque holding facility in Denver, Pennsylvania Mauritius cynomolgus macaques are housed exclusively indoors Specific Pathogen Free (SPF): B, SIV, SRV, STLV Additional service offerings: Surgically-modified models for all strains are available upon request ECG Radiology Clinical chemistry Ocular screening Custom screening Biological products: fresh and frozen tissues For more information on additional service offerings please contact us or check the technical resources section. --
Research use:
Immunology, Toxicology, Pharmacology, Diabetes, Obesity,
DA (Dark Agouti) inbred rats DA/OlaHsd Inbred rats Oncology~Transplantation~Cardiovascular Experimental allergic encephalomyelitis~Induced rheumatoid arthritis Coat: Agouti Females have a defective bile acid transport Haplotype: RT1av1 Litter average: 6.0 --
Produced in:
U.S., U.K., The Netherlands
Research use:
Oncology, Transplantation, Cardiovascular Experimental allergic encephalomyelitis, Induced rheumatoid arthritis
Dahl Salt-Sensitive/Resistant (Rapp) inbred rats SR/JrHsd Inbred rats Salt-sensitive hypertension~Heart failure~Stroke~Nephropathy Coat: Albino --
Research use:
Salt-sensitive hypertension, Heart failure, Stroke, Nephropathy
DBA/1 inbred mice DBA/1OlaHsd Inbred mice Immunology~Adjuvant-induced arthritis~Inflammation Coat: Dilute brown, non-agouti Haplotype: H-2q Litter average: 4.5 --
Produced in:
U.S., U.K., The Netherlands
Research use:
Immunology, Adjuvant-induced arthritis, Inflammation
DBA/2 inbred mice DBA/2JRccHsd Inbred mice Progressive hearing loss~Audiogenic seizures Coat: Dilute brown, non-agouti Dystrophic myocardial calcinosis Haplotype: H-2d Litter average: 4.5 --
Produced in:
U.S., U.K., The Netherlands, Israel
Research use:
Progressive hearing loss, Audiogenic seizures
Diabetic (db/db) mice BKS.Cg-+Leprdb/+Leprdb/OlaHsd Mutant mice Peripheral neuropathy~Immunodeficiency Coat: Black or misty Elevation of plasma insulin demonstrated at 10-14 days Glycosuria Hyperglycemia develops at 4-8 weeks of age Hyperinsulinemia despite severe depletion of pancreatic islet insulin-producing B-cells Leprdb is an autosomal-recessive mutation on chromosome 4 Leptin receptor deficient Obesity expressed at 4-5 weeks of age Polyphagia Polyuria/Polydipsia Proteinuria --
Produced in:
U.S., The Netherlands
Research use:
Immunology, General studies, Metabolism, Obesity, Diabetes Type 2, Myocardian Disease, Peripheral neuropathy, Immunodeficiency
Disc1 knockout rats HsdSage:SD-Disc1tm1Sage GEM rats Schizophrenia~ Bipolar disorder~ Neuronal growth and transport studies Disc1 is involved in neuronal growth and cortical development The protein also regulates the proliferation of embryonic and adult neuronal progenitor cells through the GSK3/ß-catenin pathway Preliminary reports suggest impaired prepulse inhibition in Disc1 knockout rats Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein. A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia. Disc1 is involved in neuronal growth and cortical development. The protein also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3/ß-catenin pathway. Disc1 was first identified through a translocation that segregates with schizophrenia and related psychiatric disorders in a large Scottish family, making this model useful for the study of Schizophrenia, Bipolar disorder and neuronal development.Disc1 was cryopreserved at the 12th generation. --
Produced in:
U.S.
Cryopreserved
Research use:
Schizophrenia, Bipolar disorder, Neuronal growth and transport studies
Dopamine Transporter DAT-Cre knockin rats HsdSage:LE-Slc6a3tm1(Dat-cre)Sage GEM rats Optogenetics~Expression/knockout of floxed genes~DREDD Background strain: Long Evans Hooded Cre recombinase driven by endogenous DAT promoter No observed ectopic expression of cre Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC Availability: Live colony Zygosity genotype: Homozygous This model expresses cre-recombinase under the control of the endogenous dopamine transporter promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of DAT. The DAT-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. --
Research use:
Neuroscience, Optogenetics, Expression/knockout of floxed genes, DREDD
Dunkin Hartley guinea pigs HsdDhl:DH Guinea pigs Immunology~Auditory Studies Coat: Albino Compact animal with excellent breeding performance. Individual identification via microchip on request --
Produced in:
The Netherlands
Research use:
Immunology, Auditory Studies
Dutch belted rabbits HsdHaz:(DB) SPF Rabbits Age at weaning 6 weeks Average litter size 6-8 Body temperature 100°-103°F Breeding life: male 24-30 months, female 24-30 months Environmental Temperature Range 61°-72°F (16-22◦C) Food consumption 55 gm 6-9 weeks 85-90 gm over 9 weeks Gestation period 31 days Identification methods Ear tags, tattoos, implants Photo period 14-10 Relative humidity 30% - 70% Respiration rate 35 -65 BPM Sexual maturity: male 6-9 months, female 5-8 months Water consumption 150 mL per day For more information on additional service offerings please contact us or check the technical resources section. --
Research use:
Immunology, Toxicology, Teratology, Pharmacology,
Faah knockout rats HsdSage:SD-Faahtm1Sage GEM rats Pain~Nociception~Analgesia~Cannabinoids Homozygous knockout rats exhibit complete loss of protein FAAH KO rats show an increased fear/startle reaction as observed in a functional observational battery (Irwin) FAAH KO rats show normal sensitivity to thermal pain via hot plate assay Background Strain: Sprague Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a biallelic disruption of the Faah gene encoding the fatty acid amide hydrolase. FAAH is a serine hydrolase responsible for the breakdown of endocannabinoids. This model is useful for the study of cannabinoid biology including nociception. Cannabinoids perform a variety of functions including the regulation of nociception. FAAH KO rats lack the enzyme responsible for endocannabinoid degradation,and endocannabinod levels should be elevated in this model. --
Produced in:
U.S.
Cryopreserved
Research use:
Pain, Nociception, Analgesia, Cannabinoids
Fischer 344 aged inbred rats F344/NHsd Aged Inbred rats Metabolism~Cardiovascular~Memory~Osteoarthritis~Neoplasia~Immune response~Longevity~Vision and hearing~Motor skills~Renal degeneration~Age-associated pathology~Neurobiology~Reproductive senescence Hair Loss Loss of motor skills and sensory perception Loss of vision, e.g. retinal degeneration, development of cataracts Presence of spontaneous tumors Reduced immunologic and physiologic function --
Research use:
Oncology, Toxicology, Aging, General studies, Autoimmune disease, Carcinogenicity, Allergic Encephalomyelitis, Ophthalmology, Metabolism, Cardiovascular, Memory, Osteoarthritis, Neoplasia, Immune response, Longevity, Vision and hearing, Motor skills, Renal degeneration, Age-associated pathology, Neurobiology, Reproductive senescence
Fischer 344 inbred rats F344/NHsd Inbred rats Coat: Albino Haplotype: RT1lv1 Hydrocephalic resistant Litter average: 7.5 --
Research use:
Oncology, Toxicology, Aging, General studies, Autoimmune disease, Carcinogenicity, Allergic Encephalomyelitis, Ophthalmology,
Fmr1 knockout rats HsdSage: SD-Fmr1-/nulltm1Sage GEM rats Autism~Fragile X syndrome An expansion of CGG trinucleotide repeat in Fmr1 has been implicated in Fragile X syndrome Background strain: Sprague Dawley Homozygous knockout rats display total loss of protein via Western blot Preliminary results suggest Fmr1 knockout rats possess perseverative chewing behavior and decreased juvenile play This gene is X-linked This model was created in collaboration with Autism Speaks and underwent phenotypic characterization by Dr. Richard Paylor. Availability: Live colony Zygosity genotype: Homozygous (Females) / Hemizygous (Males) This model contains a deletion of the Fragile X mental retardation 1 gene (Fmr1). Mutations in Fmr1 result in Fragile X syndrome, the leading monogenic cause of autism, making this rat useful for the study of both Fragile X syndrome and autism. The X-linked gene Fmr1 produces the fragile X metal retardation protein, or FMRP. FMRP is essential for normal mental development. An expansion of the trinucleotide CGG repeat in the Fmr1 gene is responsible for fragile X syndrome, a syndrome characterized by autism and mental disability. --
Research use:
Neuroscience, Autism, Fragile X syndrome
FVB inbred mice FVB/NHan®Hsd Inbred mice Transgenic model development Coat: Albino Fertilized eggs contain large and prominant pronuclei Haplotype: H-2q Impaired vision due to the homozygosity of the recessive rd (retinal degeneration) mutation Litter average: 8.5 Males are highly aggressive Swiss background mouse with good reproductive characteristics --
Produced in:
U.S., U.K., The Netherlands, Israel
Research use:
Transgenic model development
Gabrb3 knockout rats HsdSage:SD-Gabrb3tm1Sage GEM rats Autism~ Prader-Willi syndrome~ Epilepsy This model was created in collaboration with Autism Speaks 8 bp deletion in Gabrb3 Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Generated in conjunction with Autism Speaks, this knockout rat model possesses an 8 bp deletion in the gamma-aminobutyric acid type A receptor beta3 subunit protein encoded by the Gabrb3 gene. Gabrb3 has been associated with several disorders including Prader-Willi syndrome, epilepsy and autism. --
Produced in:
U.S.
Cryopreserved
Research use:
Autism, Prader-Willi syndrome, Epilepsy
Golden syrian hamsters HsdHan®:AURA Hamsters Syrian Hamster Embryo (SHE) Cell Transformation Assay~Hypercholesterolemia~Hibernation Coat: Golden brown and white Excellent reproductive performance Litter average: 9.0 --
Research use:
Toxicology, General studies, Behavior, Infectious disease, Carcinogenicity, Syrian Hamster Embryo (SHE) Cell Transformation Assay, Hypercholesterolemia, Hibernation
hApoE2 knockin rats HsdSage:SD-ApoE2tm1(hApoE2)Sage GEM rats Alzheimer's disease~Dopaminergic cell toxicity Background strain: Sprague Dawley Availability: Live colony Zygosity genotype: Homozygous Human apolipoprotein E (ApoE) is primarily present in the liver, kidney, and spleen, where it plays a critical role in cholesterol and lipid transport and metabolism. In the central nervous system, ApoE is synthesized and secreted by astrocytes, microglia, and neurons where it is involved in injury repair. Human ApoE (hApoE) exists as three major isoforms, ApoE2, ApoE3 and ApoE4, which are the products of three alleles at a single gene locus on the long arm of chromosome 19 in the human. hApoE2 is thought to be protective of AD, hApoE3 seems to be WT or neutral, and hApoE4 appears to yield a higher incidence for Alzheimer’s disease. In this hApoE2 knock-in rat, the rat endogenous ApoE codon region is replaced with the corresponding part of human ApoE2. --
Research use:
Alzheimer's disease, Dopaminergic cell toxicity
hApoE3 knockin rats HsdSage:SD-ApoE3tm1(hApoE3)Sage GEM rats Alzheimer's disease~Dopaminergic cell toxicity Background strain: Sprague Dawley Availability: Live Colony Zygosity genotype: Homozygous Human apolipoprotein E (ApoE) is primarily present in the liver, kidney, and spleen, where it plays a critical role in cholesterol and lipid transport and metabolism. In the central nervous system, ApoE is synthesized and secreted by astrocytes, microglia, and neurons where it is involved in injury repair. Human ApoE (hApoE) exists as three major isoforms, ApoE2, ApoE3 and ApoE4, which are the products of three alleles at a single gene locus on the long arm of chromosome 19 in the human. hApoE2 is thought to be protective of AD, hApoE3 seems to be WT or neutral, and hApoE4 appears to yield a higher incidence for Alzheimer’s disease. In this hApoE3 knock-in rat, the rat endogenous ApoE codon region is replaced with the corresponding part of human ApoE3. --
Research use:
Alzheimer's disease, Dopaminergic cell toxicity
hApoE4 knockin rats HsdSage:SD-ApoE4tm1(hApoE4)Sage GEM rats Alzheimer's disease~Neurodegenerative diseases Background strain: Sprague Dawley Homozygous replacement of the Rat ApoE gene with the Human ApoE4 gene Availability: Live colony Zygosity genotype: Homozygous Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Additionally, the 4 allele of ApoE (ApoE4) is a major risk factor for Alzheimer's disease (AD), with possession of at least one ApoE4 allele in 40-65% of patients with AD and a patient with 2 ApoE4 alleles having up to 20 times the risk of developing AD. ApoE4 has been implicated in Alzheimer's disease and cognition, making this a useful model for the study of atherosclerosis, Alzheimer's and nerve injury. --
Research use:
Alzheimer's disease, Neurodegenerative diseases
Holtzman® outbred rats HsdHot:Holtzman® SD® Outbred rats Oncology~Teratology~General studies~Toxicology~Neurology~Reproduction Coat: Albino Litter average: 11.0 --
Research use:
Oncology, Teratology, General studies, Toxicology, Neurology, Reproduction
Sprague Dawley® outbred rats Hsd:Sprague Dawley® SD® Outbred rats Coat: Albino Docile disposition Excellent reproductive performance and maternal characteristics Litter average: 11.0 Most widely-used outbred rat in animal research --
Produced in:
U.S., U.K., The Netherlands, Israel
Research use:
Oncology, Toxicology, Aging, General studies, Teratology, Cardiovascular, Neuroscience, Nutrition, Reproductive, Diet induced obesity,
NMRI nude mice HsdCpb:NMRI-Foxn1nu/Foxn1+ Mutant mice Transplantation~Immunology~Autoimmune disease~Antibody production B-cells function normal Coat: Albino Dysfunctional rudimentary thymus Foxn1nu/Foxn1+ heterogygotes do not show partial expression of the nu phenotype Litter Average: 7 No generation of cytotoxic effector cells No graft versus host response Phenotypically hairless (sparse, intermittent hair growth possible) T-cell deficient The nu allele on chromosome 11 is an autosomal recessive mutation --
Research use:
Oncology, Tumor growth, Transplantation, Immunology, Autoimmune disease, Antibody production
ICR (CD-1®) outbred mice Hsd:ICR (CD-1) Outbred mice Coat: Albino Docile disposition Excellent reproductive and maternal characteristics High incidence of retinal degeneration (Pde6brd1) Litter average: 11.5 Most widely-used outbred mouse --
Produced in:
U.S., U.K., The Netherlands, Israel
Research use:
Oncology, Toxicology, Aging, General studies, Teratology, Vaccines,
Ldlr knockout rats HsdSage:SD-Ldlrtm1Sage GEM rats Atherosclerosis~Hypertension~Insulin resistant~Atherogenesis~Lipoprotein - Cholesterol transportation~Metabolism (Triglyceride - Cholesterol)~ObesityType 2 diabetes Background strain: Sprague Dawley Homozygous knockout rats display loss of LDLR protein via Western blot Homozygous knockout rats have increased body weight as compared to wild type Homozygous knockout rats show significantly elevated serum cholesterol levels Possesses a 337 bp deletion and 4 bp insertion within Exon 4 on chromosome 8 Availability: Cryopreserved as heterozygous embryos Zygosity genotype: Homozygous The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels. Ldlr mediates the endocytosis of cholesterol-rich low-density lipoproteins (LDL) and is important for the proper regulation of LDL circulation within the blood. Expressed in the liver, loss of function of Ldlr leads to accumulation of excess LDL, which directly contributes to atherosclerosis, making this a useful model for the study of cardiovascular disease. --
Produced in:
U.S.
Cryopreserved
Research use:
Cardiovascular, Atherosclerosis, Hypertension, Insulin resistant, Atherogenesis, Lipoprotein - Cholesterol transportation, Metabolism (Triglyceride - Cholesterol), ObesityType 2 diabetes
Leptin knockout rats HsdSage:SD-Leptm1Sage GEM rats Obesity~Type II diabetes~Atherogenesis~Atherosclerosis~HypertensionInsulin resistance~Lipoprotein/Cholesterol transportation~Metabolism (Triglyceride/Cholesterol) This model possesses a 151 bp deletion within Exon 1 on chromosome 4 Homozygous knockout rats display loss of Leptin protein via Western blot Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates Homozygous knockout rats demonstrate insulin resistance Homozygous knockout rats show greatly elevated serum cholesterol levels Background Strain:Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Leptin is essential for energy intake and expenditure. It is one of the most important adipose-derived hormones, being primarily expressed in adipocytes of white adipose tissue. Loss of function of Leptin creates an uncontrolled appetite leading to severe obesity and abnormal metabolism, making this a useful model for the study of lifestyle diseases, such as obesity, diabetes, atherosclerosis, high cholesterol and high blood pressure. --
Produced in:
U.S.
Cryopreserved
Research use:
Obesity, Type II diabetes, Atherogenesis, Atherosclerosis, HypertensionInsulin resistance, Lipoprotein/Cholesterol transportation, Metabolism (Triglyceride/Cholesterol)
Lewis inbred rats LEW/Han®Hsd Inbred rats Adjuvant-induced arthritis~Experimental allergic encephalomyelitis Coat: Albino Docile disposition Haplotype: RT1l Inbred recipient for several congenic strains Increased levels of serum thyroxine, insulin, and growth hormone Litter average: 7.5 Susceptible to induction of autoimmune disease --
Produced in:
U.S., U.K., The Netherlands, Israel
Research use:
Immunology, Oncology, Transplantation, General studies, Behavior, Arthritis, Adjuvant-induced arthritis, Experimental allergic encephalomyelitis
Lgals1 (Gal1) knockout rats HsdSage:SD-Lgals1tm1Sage GEM rats Rheumatoid arthritis~ Inflammation/Autoimmune disorders~ Asthma~ Multiple sclerosis~ Thrombosis/Cardiac fibrosis~ Vascular defects~ Platelet defects/Platelet aggregation~ Renal dysplasia~ Crohn's disease~ Colitis Homozygous knockout rats display loss of LGALS1 protein via Western blot Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Galectins have been implicated in inflammation and cancer, and are useful targets for development of new anti-inflammatory and anticancer therapies. LGALS1 (GAL1) may act as an autocrine negative growth factor that regulates cell proliferation. --
Produced in:
U.S.
Cryopreserved
Research use:
Rheumatoid arthritis, Inflammation/Autoimmune disorders, Asthma, Multiple sclerosis, Thrombosis/Cardiac fibrosis, Vascular defects, Platelet defects/Platelet aggregation, Renal dysplasia, Crohn's disease, Colitis
Lister Hooded outbred rats HsdOla:LH Outbred rats Behavior Coat: Black-hooded Disposition: Docile Litter Average: 10.0 Slow growth rate --
Produced in:
U.K., The Netherlands
Long Evans (blue spruce) outbred rats HsdBlu:LE Outbred rats Nutrition~Diet-induced obesity Coat: Black-hooded Good maternal characteristics Individual housing of males recommended Litter average: 10 --
Research use:
General studies, Behavior, Metabolism, Nutrition, Diet-induced obesity
Lrrk1 knockout rats HsdSage:LE-Lrrk1tm1Sage GEM rats Parkinson's disease~Neuronal apoptosis Background strain: Long Evans Hooded Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk1 gene, encoding for the leucine-rich repeat kinase 1. This model is useful in understanding Lrrk1 biology. --
Produced in:
U.S.
Cryopreserved
Research use:
Parkinson's disease, Neuronal apoptosis
Lrrk1-Lrrk2 knockout rats HsdSage:LE-Lrrk1/Lrrk2tm1Sage GEM rats Parkinson's disease~Neuronal apoptosis Background strain: Long Evans Hooded Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Developed in collaboration with The Michael J. Fox Foundation, this model is a double knockout that contains deletions of both the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2, as well as the Lrrk1 gene, encoding for the leucine-rich repeat kinase 1. Mutations in Lrrk2 are the most common monogenic cause of Parkinson's disease. This model is useful in understanding Lrrk biology. --
Produced in:
U.S.
Cryopreserved
Research use:
Neuroscience, Parkinson's disease, Neuronal apoptosis
Lrrk2 knockout rats HsdSage:LE-Lrrktm1Sage GEM rats Parkinson's disease~Neuronal apoptosis Background strain: Long Evans Hooded Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot Lrrk2 knockout rats are significantly larger than wild type controls Lrrk2 knockout rats display dark kidneys, similar to observations made in Lrrk2 knockout mice Availability: Live colony Zygosity genotype: Homozygous Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2. Mutations in Lrrk2 are the most common monogenic cause of Parkinson's disease. This model is useful in understanding Lrrk2 biology. Lrrk2 mutations account for 5-6% of familial Parkinson's dieases and 1-3% in sporadic PD. Collectively, these mutations result in the most common cause of PD, making this an important model for the study of Parkinson's disease. --
Research use:
Neuroscience, Parkinson's disease, Neuronal apoptosis
Mdr1a knockout rats HsdSage:SD-Mdr1atm1Sage GEM rats DMPK assay~PK-PD efflux assay~Neurotoxicology~Formulation drug-drug interactions~Drug resistance~Blood brain barrier efflux~Efficacy Background strain: Sprague Dawley Biallelic 20 bp deletion within Abcba1 gene Homozygous knockout rats display total loss of protein via Western blot Increased oral bioavailability of P-gp-specific substrates Availability: Live colony Zygosity genotype: Homozygous P-glycoprotein plays a critical role in efflux for both brain and liver. Homozygous null Mdr1a rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp-specific substrates. MDR1 encodes for P-glycoprotein and is a membrane-bound drug transporter expressed in the brain and intestine. It effectively blocks drugs from crossing the blood-brain barrier. P-gp can confer multiple drug resistance to tumor cells. Absence of P-gp creates a functional deficiency in the blood-brain barrier and results in elevated drug levels in many tissues, making this a useful model for efflux assay, efficacy, formulation, tissue distribution, studying neurotoxicology and chemotherapeutic agents. --
Research use:
ADMET, DMPK assay, PK-PD efflux assay, Neurotoxicology, Formulation drug-drug interactions, Drug resistance, Blood brain barrier efflux, Efficacy
Mdr1a-1b knockout rats HsdSage:SD-Mdr1atm1SageMdr1btm1Sage GEM rats DMPK assay~PK-PD efflux assay~Neurotoxicology~Formulation drug-drug interactions~Drug resistance~Blood brain barrier efflux~Efficacy Background strain: Sprague Dawley Mdr1a (Abcba1) and Mdr1b (Abc1b) have both been knocked out as a large deletion Availability: Live colony Zygosity genotype: Homozygous P-glycoprotein plays a critical role in efflux for both brain and liver. Homozygous null Mdr1a rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp-specific substrates. MDR1 encodes for P-glycoprotein and is a membrane-bound drug transporter expressed in the brain and intestine. It effectively blocks drugs from crossing the blood-brain barrier. P-gp can confer multiple drug resistance to tumor cells. Absence of P-gp creates a functional deficiency in the blood-brain barrier and results in elevated drug levels in many tissues, making this a useful model for efflux assay, efficacy, formulation, tissue distribution, studying neurotoxicology and chemotherapeutic agents. --
Research use:
DMPK assay, PK-PD efflux assay, Neurotoxicology, Formulation drug-drug interactions, Drug resistance, Blood brain barrier efflux, Efficacy
Mdr1a-Bcrp knockout rats HsdSage:SD-Mdr1atm1SageAbcg2tm1Sage GEM rats DMPK assay~PK-PD efflux assay~Neurotoxicology~Formulation drug-drug interactions~Drug resistance~Blood brain barrier efflux~Efficacy Background strain: Sprague Dawley Biallelic 20 bp deletion within Abcba1 gene and 588 bp deletion within the Abcg2 gene Homozygous knockouts exhibit complete loss of ApoE protein via Western blot Increased oral bioavailability of P-gp and Bcrp specific substrates Availability: Live colony Zygosity genotype: Homozygous P-gp and Bcrp both play a critical role in efflux for brain. Double homozygous null Mdr1a-Bcrp rats display increased exposure to CNS drugs in the brain, as well as increased bioavailability in the plasma for P-gp and Bcrp specific substrates. MDR1 and BCRP are membrane-bound drug transporters expressed in the brain. Each effectively blocks specific drugs from crossing the blood-brain barrier. P-gp and Bcrp can confer multiple drug resistance to tumor cells. Absence of P-gp and Bcrp creates a functional deficiency in the blood-brain barrier and results in elevated drug levels in many tissues, making this a useful model for efflux assay, efficacy, formulation, tissue distribution, studying neurotoxicology and chemotherapeutic agents. --
Research use:
ADMET, DMPK assay, PK-PD efflux assay, Neurotoxicology, Formulation drug-drug interactions, Drug resistance, Blood brain barrier efflux, Efficacy
MeCP2 knockout rats HsdSage:SD-Mecp2tm1Sage GEM rats Autism~Cognition~Rett syndrome Background strain: Sprague Dawley Hemi males are compromised at 6 weeks of age Knockout rats exhibit complete loss of target protein as demonstrated by Western blot Mutations in methyl-CpG-binding protein (MeCP2) result in Rett syndrome, a leading cause of intellectual disabilities in girls Availability: Cryopreserved as heterozygous female embryos (X-Linked) Zygosity: Heterozygous Females This model contains a deletion of the methyl-CpG-binding protein (MeCP2)and is useful for the study of Rett syndrome. The gene is X-Linked. Mutations in MeCP2 have been linked to the development of Rett syndrome, a leading cause of intellectual disabilities in girls. --
Produced in:
U.S.
Cryopreserved
Research use:
Neuroscience, Autism, Cognition, Rett syndrome
Met knockout rats HsdSage:SD-Mettm1Sage GEM rats Autism Spectrum Disorders~ Synaptic Plasticity~ Autoimmune disorders This model possesses a 17 base pair deletion in exon 8 of MET This model is provided as a heterozygous knockout; homozygous knockout of MET is not viable Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Generated in partnership with Autism Speaks, this model possesses a deletion in exon 8 of MET receptor tyrosine kinase (MET). Mutations in MET have been associated with the autism spectrum disorders in human patients, and this model is useful for the study of autism. Homozygous knockout of MET is embryonic lethal. --
Produced in:
U.S.
Cryopreserved
Research use:
Autism Spectrum Disorders, Synaptic Plasticity, Autoimmune disorders
mGluR5 knockout rats HsdSage:SD-Grm5tm1Sage GEM rats Autism~Fragile X syndrome~Anxiety~Cognition~Pain~Schizophrenia Background strain: Sprague Dawley GlurR5 antagonists are being pursued as potential therapeutics for Fragile X syndrome and autism spectrum disorders mGluR5 is implicated in the neuropharmacology of cognition, anxiety, addiction and pain The function of this receptor is altered in Fragile X syndromem Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a biallelic deletion of the metabotropic glutamate receptor 5 (mGluR5 or Grm5). mGluR5 function is altered in Fragile X syndrome, and mGluR5 has emerged as a promising drug target for both Fragile X syndrome and autism spectrum disorders. --
Produced in:
U.S.
Cryopreserved
Research use:
Neuroscience, Autism, Fragile X syndrome, Anxiety, Cognition, Pain, Schizophrenia
Mrp1 knockout rats HsdSage:SD-Abcc1atm1Sage GEM rats Drug resistance~Drug transport~Studying excretion pathways in cancer Background strain: Sprague Dawley Decreased transport of glutatione-conjugated substrates Homozygous knockout rats display total loss of protein via Western blot Increased bioavailability of specific substrate Fluorescein Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a 43 base pair bi-allelic deletion within the Mrp1 gene, synonym Abcc1a (ATP-binding cassette, sub-family C [CFTR/MRP], member 1a), encoding an ATP-dependent drug transporter. Mrp1 is a multispecific organic anion transporter that extrudes glutathione-, glucouronide- or sulfate-conjugated substrates (steroids, leukotrienes, etc.), as well as xenobiotic drugs out of cells. Mrp1 can confer multiple drug resistance to tumor cells. Absence of Mrp1 creates a functional deficiency in the cellular transport of some substrates and results in compromised inflammatory response, making this model useful for studying drug transport in inflammatory stimulus response and chemotherapeutic agents. --
Research use:
Drug resistance, Drug transport, Studying excretion pathways in cancer
Mrp2 knockout rats HsdSage:SD-Abcc2tm1Sage GEM rats Tissue distribution~DMPKPK/PDFormulation~Dubin-Johnson syndrome~Efficacy Drug-drug interactions~Efflux assays Background strain: Sprague Dawley Biallelic 726 bp deletion within Abcc2 gene Decreased transport of endogenous glutathione Homozygous knockout rats display total loss of protein via Western blot Hyperbilirubinemia Availability: Cryopreserved as heterozygous embryos Zygosity: Homozygous Homozygous Mrp2 null rats display compromised biliary excretion and hyperbilirubinemia. This results in accumulation of glutathione-conjugated drugs in the liver. Mrp2 is expressed in the liver and functions in biliary transport. The gene's substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells. This model is useful for forumational, efficacy, tissue distribution, and DMPK assays --
Research use:
ADMET, Tissue distribution, DMPKPK/PDFormulation, Dubin-Johnson syndrome, Efficacy Drug-drug interactions, Efflux assays
ND4 Swiss webster outbred mice Hsd:ND4 Outbred mice Toxicology~Infectious disease~Retinal ischemia research~Pain and neuroscience Coat: Albino --
Research use:
Toxicology, Infectious disease, Retinal ischemia research, Pain and neuroscience
Neurexin1-Nrxn1 knockout rats HsdSage:SD-Nrxn1tm1Sage GEM rats Autism~Schizophrenia~Synaptic Plasticity Background strain: Sprague Dawley Biallelic 726 bp deletion within Abcc2 gene Decreased transport of endogenous glutathione Homozygous knockouts display total loss of protein via Western blot Hyperbilirubinemia Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a biallelic deletion of the Neurexin 1 gene (Nrxn1). Mutations in Nrxn1 have been associated with autism spectrum disorders (ASD) and this model is useful for understanding the role of neurexins in the development of ASD. --
Produced in:
U.S.
Cryopreserved
Research use:
Neuroscience, Autism, Schizophrenia, Synaptic Plasticity
Neuroligin 3 (Nlgn3) knockout rats HsdSage:SD-Nlgn3tm1Sage GEM rats Autism~Asperger's syndrome~Synaptic Plasticity Background strain: Sprague Dawley Copy number variations in Neurexin 1 have been linked to both ASD and schizophrenia Deletions in Neurexin 1 are present in ~0.5% of patients with ASD Neurexins are important for postsynaptic differentiation, especially so for GABA synaptic connections This model was created in collaboration with Autism Speaks and underwent phenotypic characterization by Dr. Richard Paylor. Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger's syndrome. This model is useful for understanding the role of neuroligins in the development of autism spectrum disorders. Neuroligins are neuronal cell-surface proteins that bind with beta neurexins, spanning synapses. Neuroligins may play a role in synaptic plasticity and mutations in neuroligin 3 have been associated with autism and Asperger syndrome. --
Produced in:
U.S.
Cryopreserved
Research use:
Neuroscience, Autism, Asperger's syndrome, Synaptic Plasticity
New Zealand white rabbits HsdHra:(NZW) SPF Rabbits Dermatology~Ophthalmology~Biomedical Research~Atherosclerosis~Osteology~Studies~Renal Studies Coat: Albino Consistently test negative for Bordetella bronchiseptica and Pasteurella multocida (since 1996) Individual identification via ear tag, tattoo, or microchip available upon request Litter Average: 8.5 Technicians handle and socialize animals beginning at birth for a more docile demeanor Utilize production software with capabilities of tracing individual rabbit lineage over multiple generations For more information please contact us or check the technical resources section. Coat: Albino Average litter size: 7-10 Body temperature: 100°-103°F Respiration rate: 35 -65 BPM Gestation period: 31 days Age at weaning: 5 weeks Environmental Temperature Range 61°-72°F (16°-22°C) Relative humidity: 30-70% Photo period: 14/10 Sexual maturity: Male: 6-9 months | Female: 5-8 months Breeding life: Male: 24-30 months | Female: 24-30 months Identification methods: Ear tags, tattoos, implants Food consumption: 125 gm Water consumption: 150 mL per day Identification methods: Ear tags, tattoos, implants --
Produced in:
U.S., U.K., Israel
Research use:
Toxicology, Antibody production, Cardiovascular, Dermatology, Ophthalmology, Biomedical Research, Atherosclerosis, Osteology, Studies, Renal Studies
NIH inbred mice NIH/OlaHsd Inbred mice Coat: Albino Excellent reproductive performance Haplotype: H-2q This strain carries gene rd, causing retinal degeneration --
NIH Swiss outbred mice HSD:NIHS Outbred mice General purpose studies Coat: Albino --
Research use:
, General purpose studies
NMRI nude mice HsdCpb:NMRI-Foxn1nu Mutant mice Transplantation~Immunology~Autoimmune disease~Antibody production B-cells function normal Coat: Albino Dysfunctional rudimentary thymus Foxn1nu/Foxn1+ heterogygotes do not show partial expression of the nu phenotype Litter Average: 7 No generation of cytotoxic effector cells No graft versus host response Phenotypically hairless (sparse, intermittent hair growth possible) T-cell deficient The nu allele on chromosome 11 is an autosomal recessive mutation --
Research use:
Oncology, Tumor growth, Transplantation, Immunology, Autoimmune disease, Antibody production
NMRI outbred mice HsdWin:NMRI Outbred mice Coat: Albino Docile disposition Excellent reproductive and maternal characteristics High incidence of retinal degeneration (Pde6brd1) Litter Average 10.7 Most widely-used outbred mouse --
Produced in:
The Netherlands
Research use:
Immunology, Transplantation, Antibody production, Other,
NOD.SCID mice NOD.CB17-Prkdcscid/NCrHsd Mutant mice Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16 Coat: Albino Development of autoimmune diabetes does not occur due to severe combined immunodeficiency Highly susceptible to opportunistic viral and bacterial infection Natural Killer (NK) cell, macrophage and granulocyte numbers and function are reduced Severe combined immunodeficiency affecting T- and B-lymphocyte development Spontaneous thymic lymphomas As SCID mice age, a variable percentage become 'leaky' from spontaneous development of functional T- and B-lymphocytes --
Produced in:
U.S., Israel, France
Research use:
Transplantation, Tumor growth,
Non-Swiss albino outbred mice Hsd:NSA(CF-1®) Outbred mice Toxicology~Infectious disease Coat: Albino --
Research use:
Toxicology, Infectious disease
NZB inbred mice NZB/OlaHsd Inbred mice Coat: Black Haplotype: H-2d Mouse model for autoimmune hemolytic anemia, immune complex glomerulonephritis and systemic lupus erythematosus Poor reproductive performance --
NZBNZWF1 hybrid mice NZBNZWF1/OlaHsd Hybrid mice Haplotype H-2d/z Model for systemic lupus erythematosus Will accept transplanted tissues from either parent --
NZW inbred mice NZW/OlaHsd Inbred mice Coat: Albino Haplotype H-2z --
Oat1 knockout rats HsdSage:SD-Slc22a6tm1Sage GEM rats Drug transport~ Drug-drug interactions~ Drug metabolism~ Hepatotoxicity Availability: Cryopreserved as homozygous embryos Zygosity:Homozygous This model contains a biallelic deletion of the organic anion transporter 1 (OAT1), also known as solute carrier family 22 member 6 (SLC22A6). Oat1 plays a central role in renal organic anion transport. Along with Oat3, Oat1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys- making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver. --
Produced in:
U.S.
Cryopreserved
Research use:
Drug transport, Drug-drug interactions, Drug metabolism, Hepatotoxicity
Oat3 knockout rats HsdSage:SD-Slc22a8tm1Sage GEM rats Drug transport~ Drug-drug interactions~ Drug metabolism~ Hepatotoxicity Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a biallelic deletion of the organic anion transporter 3 (Oat3), also known as solute carrier family 22 member 8 (SLC22A8). Oat3 plays a central role in renal organic anion transport. Along with Oat1, Oat3 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys- making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver. --
Produced in:
U.S.
Cryopreserved
Research use:
Drug transport, Drug-drug interactions, Drug metabolism, Hepatotoxicity
Obese (ob/ob) mice B6.V-Lepob/OlaHsd Mutant mice Gerontology Adipocyte hyperplasia Coat: Black Defective body temperature regulation Hyperinsulinemia Hyperlipemia Hyperphagia Insulin-resistant Lepob autosomal-recessive mutation on chromosome 6 Leptin protein deficient Moderate transient hyperglycemia Obesity expressed at 4 to 5 weeks of age Sterile homozygous females --
Research use:
General studies, Diabetes, Obesity, Nutrition, Gerontology
Oct1 knockout rats HsdSage:SD-Slc22a1tm1Sage GEM rats Drug-drug interactions~Drug metabolism~Drug transport~Hepatotoxicity Background strain: Sprague Dawley Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot Availability: Cryopreserved as heterozygous embryos Zygosity: Homozygous This model contains an 11 bp bi-allelic deletion within exon 1 of the Slc22a1 solute carrier family 22 (organic cation transporter), member 1, encoding for the basolateral hepatocyte uptake transporter OCT1. Oct1 is involved in disposition and excretion through its role in xenobiotic uptake in the basolateral membrane of the liver. Polymorphisms within the gene also have clinical relevance - making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver.Oct1 was cryopreserved at the 12th generation. For more information on cryorecovery, please follow the link below. --
Research use:
Drug-drug interactions, Drug metabolism, Drug transport, Hepatotoxicity
Oct2 knockout rats HsdSage:SD-Slc22a2tm1Sage GEM rats Drug-drug interactions~Drug metabolism~Drug transport~Hepatotoxicity Oct1 (-/-) rats have increased exposure to specific substrates Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous A related model Oct1 (-/-) rats have increased exposure to specific substrates This model contains a biallelic deletion within the Slc22a2 solute carrier family 22 (organic cation transporter), member 2, encoding for the basolateral hepatocyte uptake transporter OCT2. Oct2 is involved in disposition and excretion through its role in xenobiotic uptake in the basolateral membrane of the liver. Polymorphisms within the gene also have clinical relevance - making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver. --
Research use:
Drug-drug interactions, Drug metabolism, Drug transport, Hepatotoxicity
Oprm1 knockout rats HsdSage:SD-Oprm1tm1Sage GEM rats Addiction~Analgesia~Nociception~Pain 11 base pair deletion in exon 2 Background strain: Sprague Dawley Early stop codon in exon 3 Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model possesses an 11 base pair deletion in exon 2 of the Oprm1 gene, leading to an early stop codon in exon 3. Oprm1 encodes the mu opioid receptor 1 (MOR), the major target of most clinically used opioids. This model is useful for applications investigating nociception, and is particularly useful for discrimination among opioid receptor subtypes. --
Produced in:
U.S.
Cryopreserved
Research use:
Addiction, Analgesia, Nociception, Pain
p53 knockout rats HsdSage:SD-Tp53tm1Sage GEM rats Xenografts~ Vaccine development~ Cancer~ Autoimmune disease~ Infectious disease~ Hematopoiesis Monoallelic 11 base pair deletion in Tp53 Broad tumor spectrum High degree of tumor malignancy Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Homozygous null Tp53 rats display onset of tumors at ~4 months of age. A high degree of malignancy is observed across a broad spectrum of tumors. Heterozygous rats have a delayed onset of spontaneous tumors, making them valuable for carcinogenicity screening, as well as studying efficacy of chemopreventive and therapeutic treatment. p53 is a tumor suppressor protein encoded by the Tp53 gene. Its role in cell cycle regulation and stabilization for preventing genome mutation is observable among a wide variety of multicellular organisms, including humans, rodents, frogs and fish. Heterozygous rats deficient in p53 protein are prone to spontaneous tumors, making them valuable for in vivo screening of carcinogenicity, as well as studying chemopreventive and therapeutic treatment. --
Produced in:
U.S.
Cryopreserved
Research use:
Xenografts, Vaccine development, Cancer, Autoimmune disease, Infectious disease, Hematopoiesis
p75NTR knockout rats HsdSage:SD-Ngfrtm1Sage GEM rats Neuronal apoptosis~Analgesia~Nociception~Pain 11 base pair deletion in exon 2 Background strain: Sprague Dawley Early stop codon in exon 3 Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Along with TrkA, p75NTR is a receptor for the nerve growth receptor and is important in nociception. The p75NTR knockout rat is useful for pain research. NGF dysfunction has been linked to neuropathic and osteoarthritic pain along with hyperalgesia. Inhibition of NGF, including inhibition of the p75NTR, is being pursued as a potential analgesic. --
Produced in:
U.S.
Cryopreserved
Research use:
Neuroscience, Neuronal apoptosis, Analgesia, Nociception, Pain
Park2 Parkin knockout rats HsdSage:LE-Park2tm1Sage GEM rats Parkinson's disease~Dopaminergic cell toxicity Background strain: Long Evans Hooded Homozygous knockout rats display total loss of protein via Western blot Park2 knockout rats show normal motor performance on rotarod Availability: Live colony Zygosity genotype: Homozygous Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Park2 (Parkinson disease [autosomal recessive, juvenile] 2) gene, encoding for the protein Parkin. Mutations in Parkin have been linked to early-onset Parkinson's disease (PD), making this model useful to further understand the role of Parkin in PD. In humans, loss of function of Park2 leads to a form of familial Parkinson's disease. The Parkin protein is part of the ubiquitin-proteasomal enzyme pathway and may help degrade other proteins that are toxic to neurons. Roughly 20% of patients with Parkinson's disease onset before age 40 have mutations within Park2, making this an ideal model for the study of Parkinson's disease. --
Research use:
Neuroscience, Parkinson's disease, Dopaminergic cell toxicity
Park7 DJ-1 knockout rats HsdSage:LE-Park7tm1Sage GEM rats Parkinson's disease~Dopaminergic cell toxicity Approximately 30% of DJ-1 knockout rats show a hindlimb-dragging phenotype that emerges at 4-6 weeks of age and worsens at 5 months Background strain: Long Evans Hooded DJ-1 knockout rats show impaired open-field mobility at 8 months of age. DJ-1 knockout rats show gait impairments at 8 months of age Homozygous knockout rats display total loss of protein via Western blot Preliminary reports have suggested DJ-1 knockout rats show a ~50% reduction in dopaminergic neurons in the substantia nigra at 8 months of age Availability: Live Colony Zygosity genotype: Homozygous Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Park7 (Protein deglycase DJ-1) gene, encoding for the protein DJ-1. Mutations in DJ-1 have been linked to autosomal recessive early-onset Parkinson's disease (PD), making this model useful to further understand the role of DJ-1 in PD. In humans, loss of function of Park7 leads to a form of early-onset Parkinson's disease. This occurs due to the role Park7 plays in protecting neurons from oxidative stress and cell death, making this an ideal model for the study of Parkinson's disease. --
Research use:
Neuroscience, Parkinson's disease, Dopaminergic cell toxicity
Parvalbumin-Cre knockin rats HsdSage:LE-Pvalbtm1(IRES-Cre)Sage GEM rats Optogenetics~Expression/knockout of floxed genes Background strain: Long Evans Hooded Cre recombinase driven by endogenous Paravalbumin promoter No observed ectopic expression of cre Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC Availability: Live colony Zygosity genotype: Homozygous This model expresses cre-recombinase under the control of the endogenous paravalbumin (Pvalb) promoter enabling specific expression in inhibitory neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Pvalb. The Paravalbumin-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. --
Research use:
Neuroscience, Optogenetics, Expression/knockout of floxed genes
Pde4b knockout rats HsdSage:SD-Pde4btm1Sage GEM rats Schizophrenia~ Bipolar disorder~ Neuronal growth and transport studies Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model is a biallelic deletion of the Pde4b gene that regulates and mediates cellular responses to stimuli such as hormones and neurotransmitters. This model will be useful in the study of schizophrenia and bipolar disorder. --
Produced in:
U.S.
Cryopreserved
Research use:
Schizophrenia, Bipolar disorder, Neuronal growth and transport studies
Pink1 knockout rats (Park6) HsdSage:LE-Pink1tm1Sage GEM rats Parkinson's disease~Stress-induced neurological dysfunction Approximately 30% of Pink1 knockout rats display a hindlimb-dragging phenotype at 8 months of age Background strain: Long Evans Hooded Homozygous knockout rats display total loss of protein via Western blot Pink1 knockout rats show increased hindlimb fatigue at 7 weeks of age Pink1 knockout rats show increased number of hindlimb foot slips at 5 and 9 weeks of age as assessed by tapered balance beam Preliminary reports have suggested Pink1 knockout rats show a ~50% reduction in dopaminergic neurons in the substantia nigra at 8 months of age Availability: Live colony Zygosity genotype: Homozygous Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson's disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson's disease. This model is being developed in partner with the Michael J. Fox Foundation as part of our Parkinson's disease research suite. Pink1 protein kinase localizes to the mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations within this gene result in one form of autosomal recessive early-onset Parkinson's. --
Research use:
Neuroscience, Parkinson's disease, Stress-induced neurological dysfunction
Ppara knockout rats HsdSage:SD-Pparatm1Sage GEM rats Obesity~Diabetes~Inflammation~Autoimmune disorders~Cell proliferation~Lipid metabolism~Wound healing Background strain: Sprague Dawley Homozygous knockout rats display total loss of protein via Western blot Availability: Live colony Zygosity: Homozygous This model contains a bi-allelic deletion within the peroxisome proliferator-activated receptor alpha gene (Ppara). Ppara (peroxisome proliferator-activated receptor alpha gene) is a ligand activated nuclear receptor, known to be activated by free fatty acids and their derivatives. Besides the studying of lipid metabolism and diabetes, Ppar-alpha affect the expression of target genes involved in cell proliferation, cell differentiation, and in immune and inflammation responses. --
Research use:
ADMET, Obesity, Diabetes, Inflammation, Autoimmune disorders, Cell proliferation, Lipid metabolism, Wound healing
Prkdc knockout rats HsdSage:SD-Prkdctm1Sage GEM rats Tumor cell growth~Xenograft~Cancer metastasis Background strain: Sprague Dawley Homozygous knockout rats display total loss of protein via Western blot Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous The Prkdc gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). DNA-PK is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity. Mature B and T cells are critical components for an adaptive immune system. DNA-PK knockout rats have severe combined immunodeficiency (SCID) and lack of both B and T cells, due to their V(D)J recombination defect. Rats deficient in the Prkdc gene produce no mature B, T or NK cells. This SCID rat is a useful model for cancer, xenografts, vaccine development, and autoimmune and infectious disease study. --
Produced in:
U.S.
Cryopreserved
Research use:
Immunology, Tumor cell growth, Xenograft, Cancer metastasis
Pten knockout rats HsdSage:SD-Ptentm1Sage GEM rats Autism~ Cancer This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization by Dr. Richard Paylor at Baylor College of Medicine Mutations in Pten have been associated with autism Background Strain: Sprague-Dawley Availability: Cryopreserved as a mix of Heterozygous & WT embryos Zygosity: Heterozygous This model contains a monoallelic deletion of the phosphatase and tensin homolog gene (Pten). Pten mutations have been linked with autism, making this model useful for the study of autism spectrum disorders. --
Produced in:
U.S.
Cryopreserved
Research use:
Autism, Cancer
PXR knockout rats HsdSage:SD-Nr1i2tm1Sage GEM rats Xenobiotic sensor~Cytochrome p450 pathways~Drug metabolism~Cholestasis~Hepatotoxicity Background strain: Sprague Dawley Biallelic 20 bp deletion within Nr1i2 gene Lacks induction of Cyp3a1 Availability: Live colony Zygosity: Homozygous PXR is involved in the induction of cytochrome p4503A (Cyp3a) and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity. The activation of nuclear receptors, including the Pregnane X Receptor (PXR) and the Constitutive Androstane Receptor (CAR), is a common Mode of Action (MoA) for chemicals that exhibit non-genotoxic hepatocarcinogenicity in rodents. Conversely, the activation of the human PXR and/or CAR receptors is not believed to result in a carcinogenic response. Therefore, if a compound causes liver tumors in rodents, or if studies demonstrate that the compound is a nuclear receptor agonist, it is critical to unambiguously demonstrate the role of specific nuclear receptors in the rodent response, for example by using PXR or CAR KO rats. CXR has extensive experience of working with global pharmaceutical, chemical and agrochemical companies to demonstrate the absence of human relevance for nuclear-receptor mediated carcinogenicity. --
Research use:
ADMET, Xenobiotic sensor, Cytochrome p450 pathways, Drug metabolism, Cholestasis, Hepatotoxicity
PXR-CAR knockout rats HsdSage:SD-Nr1i2tm1SageNr1i3tm1Sage GEM rats Xenobiotic sensor~Cytochrome p450 pathways~Drug metabolism~Cholestasis~Hepatotoxicity Background strain: Sprague Dawley Biallelic 10 bp deletion within Nr1i3 gene Biallelic 20 bp deletion within Nr1i2 gene Availability: Live colony Zygosity: Homozygous PXR and CAR are involved in the induction of cytochrome p4503A (Cyp3a) and is abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity. This double knockout model was generated by crossing together the single PXR and Car knockout rat lines.The activation of nuclear receptors, including the Pregnane X Receptor (PXR) and the Constitutive Androstane Receptor (CAR), is a common Mode of Action (MoA) for chemicals that exhibit non-genotoxic hepatocarcinogenicity in rodents. Conversely, the activation of the human PXR and/or CAR receptors is not believed to result in a carcinogenic response. Therefore, if a compound causes liver tumors in rodents, or if studies demonstrate that the compound is a nuclear receptor agonist, it is critical to unambiguously demonstrate the role of specific nuclear receptors in the rodent response, for example by using PXR or CAR KO rats. CXR has extensive experience of working with global pharmaceutical, chemical and agrochemical companies to demonstrate the absence of human relevance for nuclear-receptor mediated carcinogenicity. --
Research use:
ADMET, Xenobiotic sensor, Cytochrome p450 pathways, Drug metabolism, Cholestasis, Hepatotoxicity
PXR/CAR/AHR knockout rats HsdSage:SD-NR1i2/NR1i3/AHRtm1Sage GEM rats Xenobiotic sensor~Cytochrome p450 pathways~Drug metabolism~Hepatotoxicity~Cholestasis Biallelic 20 bp deletion within Nr1i2 gene Biallelic 10 bp deletion within Nr1i3 gene Biallelic 760 bp deletion within Ahr gene Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous PXR, CAR, and AHR are involved in the induction of cytochrome p4503A (Cyp3a) and are abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity. This triple knockout model was generated by crossing together the three single PXR, Car, and AHR knockout rat lines. --
Produced in:
U.S.
Cryopreserved
Research use:
Xenobiotic sensor, Cytochrome p450 pathways, Drug metabolism, Hepatotoxicity, Cholestasis
Rag1 knockout rats (Fischer 344) F344-Rag1tm1Sage/SageHsd GEM rats Xenograft~Cancer metastasis~Vaccine development~Inflammation/Autoimmune disorders~Thrombosis/Cardiac fibrosis Background Strain: Fischer 344 Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes. Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag1 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, as well as the study of autoimmune and infectious diseases. --
Produced in:
U.S.
Cryopreserved
Research use:
Xenograft, Cancer metastasis, Vaccine development, Inflammation/Autoimmune disorders, Thrombosis/Cardiac fibrosis
Rag1 knockout rats | Sprague-Dawley HsdSage:SD-Rag1tm1Sage GEM rats Xenograft~Cancer metastasis~Vaccine development~Inflammation/Autoimmune disorders~Thrombosis/Cardiac fibrosis~Vascular defects~Hematopoieses~Infectious disease 29 bp deletion within Exon 2 on chromosome 3 Homozygous Rag1 knockout rats display loss of RAG1 protein via Western blot Homozygous Rag1 knockout rats show loss of B and T cells by FACS analysis Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes. Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag1 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, as well as the study of autoimmune and infectious diseases. --
Produced in:
U.S.
Cryopreserved
Research use:
Xenograft, Cancer metastasis, Vaccine development, Inflammation/Autoimmune disorders, Thrombosis/Cardiac fibrosis, Vascular defects, Hematopoieses, Infectious disease
Rag2 knockout rats (Fischer 344) F344-Rag2tm1Sage/SageHsd GEM rats Xenograft~Cancer metastasis~Vaccine development~Inflammation/Autoimmune disorders~Thrombosis/Cardiac fibrosis~Vascular defects Background Strain: Fischer 344 Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous Rag2 knockout rats completely lack B and T cells, making them ideal immuno-compromised hosts for xenograft studies. In addition, the larger size of the rat makes performing sophisticated xenograft techniques and surgeries much simpler as compared to similar studies in a mouse. Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag2 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, autoimmune and infectious diseases. --
Produced in:
U.S.
Cryopreserved
Research use:
Xenograft, Cancer metastasis, Vaccine development, Inflammation/Autoimmune disorders, Thrombosis/Cardiac fibrosis, Vascular defects
Rag2 knockout rats (Sprague Dawley) HsdSage:SD-Rag2tm1sage GEM rats Xenograft~Cancer metastasis~Inflammation - Autoimmune disorders~Thrombosis - Cardiac fibrosis~Vascular defects~Hematopoieses 2 bp deletion within Exon 3 on chromosome 3 Homozygous Rag2 knockout rats display loss of RAG2 protein via Western blot Homozygous Rag2 knockout rats show loss of B and T cells by FACS analysis Availability: Live colony Zygosity genotype: Homozygous Rag2 knockout rats completely lack B and T cells, making them ideal immuno-compromised hosts for xenograft studies. In addition, the larger size of the rat makes performing sophisticated xenograft techniques and surgeries much simpler as compared to similar studies in a mouse. Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag2 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, autoimmune and infectious diseases. --
Research use:
Oncology, Infectious disease, Vaccines, Xenograft, Cancer metastasis, Inflammation - Autoimmune disorders, Thrombosis - Cardiac fibrosis, Vascular defects, Hematopoieses
Rag2-Il2rg double knockout mice (R2G2®) B6;129-Rag2tm1FwaII2rgtm1Rsky/DwlHsd Mutant mice Infectious disease~Cancer cell transplantation Coat white-bellied, light chinchilla (light tan) Common gamma chain gene (II2rg) interrupted Decreased dendritic cells Decreased macrophage cells Decreased neutrophils Deficient in T and B cells Lacks functional receptors for IL-2, IL-4, IL-7, IL-9 and IL-15 Lacks NK cells Recombination activating gene 2 (Rag2) interrupted Severe lymphocyte development impairment --
Produced in:
U.S., U.K., Israel, France
Research use:
Immunology, Oncology, Tumor growth, Neuropathology, Infectious disease, Cancer cell transplantation
Rbfox1 knockout rats HsdSage:SD-Rbfox1tm1Sage GEM rats Autism Spectrum Disorders~Neurodegenerative Disorders This model was created in collaboration with Autism Speaks 176kb deletion in Rbfox1 Background Strain: Sprague-Dawley Availability: Cryopreserved as a mix of Heterozygous & WT embryos Zygosity: Heterozygous Generated in conjunction with Autism Speaks, this knockout rat model contains a 176 kb deletion in the RNA binding protein, fox-1 homolog (Rbfox1) gene. Rbfox1 has been associated with the autism spectrum disorders and affects the expression of other autism-linked genes. --
Produced in:
U.S.
Cryopreserved
Research use:
Autism Spectrum Disorders, Neurodegenerative Disorders
Rhesus macaques Macaca mulatta Nonhuman primates Bred on-site in Alice, Texas for Indian strain Limited availability for sexually mature animals Primate holding facilities in Alice, Texas for Chinese strain Specific Pathogen Free (SPF): B, SIV, SRV, STLV Additional service offerings: Surgically-modified models for all strains are available upon request ECG Radiology Clinical chemistry Ocular screening Custom screening Biological products: fresh and frozen tissues For more information on additional service offerings please contact us or check the technical resources section. --
Research use:
Immunology, Toxicology, Transplantation, Pharmacology, Diabetes, Obesity,
SABRA-M outbred mice HsdHu:SABRA-M Outbred mice Coat: Albino General purpose model Litter average: 8.5 --
SABRA-R outbred rats HsdHu:SABRA-R Outbred rats Coat: Albino Model for hypertension --
SAM (senescence accelerated mice) inbred mice SAMP8/TaHsd Inbred mice Geriatric pathogenesis~Senile amyloidosis (apolipoprotein A-II)~Hearing impairment~Emotional disorders Aging process~Age-dependent disorders~Senile osteoporosis~Hyperinflation of the lungs~Deficits in learning and memory~Brain atrophy~Accelerated senescence studies SAMP8/TaHsd Coat: Albino Litter Average 5.6 Accelerated aging Medium survival 12.1 months Males are highly aggressive SAMR1/TaHsd (control) Coat: Albino Litter Average 5.9 Aging control model for SAMP8 Medium survival 18.9 months Males are highly aggressive --
Produced in:
The Netherlands
Research use:
,, Geriatric pathogenesis, Senile amyloidosis (apolipoprotein A-II), Hearing impairment, Emotional disorders Aging process, Age-dependent disorders, Senile osteoporosis, Hyperinflation of the lungs, Deficits in learning and memory, Brain atrophy, Accelerated senescence studies
SCID mice C.B-17/IcrHan®Hsd-Prkdcscid Mutant mice As SCID mice age, a variable percentage become 'leaky' from the spontaneous development of functional T and B lymphocytes Autosomal-recessive, single-nucleotide polymorphism within Prkdc gene on chromosome 16 Coat: Albino Highly susceptible to opportunistic viral and bacterial infection Natural Killer (NK) cell, macrophage, and granulocyte cell numbers and function are normal Severe combined immunodeficiencyaffecting T- and B-cell development --
Produced in:
U.S., U.K., Israel, France
Research use:
Immunology, Oncology, Transplantation, Tumor growth, Imaging,
SCID/beige mice C.B-17/IcrHsd-PrkdcscidLystbg-J Mutant mice Teratology Autosomal-recessive beige (bg-J) mutation on chromosome 13 Autosomal-recessive, single-nucleotide polymorphism within Prkdc gene on chromosome 16 Coat: Albino Diminished Natural Killer (NK) cell activity relative to other SCID models Highly susceptible to opportunistic viral and bacterial infection Rudimentary thymus Severe lymphopenia --
Produced in:
U.S., Israel, France
Research use:
Immunology, Oncology, Transplantation, General studies, Tumor cell growth, Teratology
SHrN® hairless NOD.SCID mice NOD.Cg-Prkdcscidhrhr/NCrHsd Mutant mice Xenograft transplantation~Imaging applications~Humanization applications Coat: Albino Decreased dendritic cells Decreased granulocyte function Decreased macrophage function Deficient in T and B cells Inbred NK cell functional deficit No circulating complement Phenotypically hairless (sparse, intermittent hair growth possible) Severe Immunodeficiency --
Research use:
Immunology, Oncology, Xenograft transplantation, Imaging applications, Humanization applications
SJL inbred mice SJL/JCrHsd Inbred mice Immunology~Behavior Coat: Albino Haplotype: H-2s High Incidence of Reticulum Cell Sarcomas resembling Hodgkin's Disease Litter average: 6 Males can exhibit aggression among cagemates --
Produced in:
U.S., The Netherlands, Israel
Research use:
Immunology, Behavior
Spontaneously hypertensive inbred rats SHR/NHsd Inbred rats Hypertension~Insulin resistant Coat: Albino Haplotype: RT1k Hyperactive Insulin resistant Spontaneous hypertension --
Research use:
Hypertension, Insulin resistant
Sprague Dawley® aged outbred rats Hsd:Sprague Dawley® SD Aged Outbred rats Metabolism~Cardiovascular~Memory~Osteoarthritis~Neoplasia~Immune response~Longevity~Vision and hearing~Motor skills~Renal degeneration~Age-associated pathology~Neurobiology~Reproductive senescence Coat: Albino Hair Loss Loss of motor skills and sensory perception Loss of vision, e.g. retinal degeneration, development of cataracts Presence of spontaneous tumors Reduced immunologic and physiologic function --
Research use:
Metabolism, Cardiovascular, Memory, Osteoarthritis, Neoplasia, Immune response, Longevity, Vision and hearing, Motor skills, Renal degeneration, Age-associated pathology, Neurobiology, Reproductive senescence
Sst-Cre knockin rats HsdSage:LE-SSt.Cretm1sage GEM rats Optogenetics, Expression/knockout of floxed genes Background strain: Long Evans Hooded Cre recombinase driven by endogenous Somatostatin promoter No observed ectopic expression of cre Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC Availability: Live colony Zygosity genotype: Homozygous This model expresses cre-recombinase under the control of the endogenous somatostatin promoter enabling specific expression in somatostatin neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Sst. The Sst-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. --
Research use:
Optogenetics, Expression/knockout of floxed genes
Tbx21 (T-beta) knockout rats HsdSage:SD-Tbx21tm1Sage GEM rats Rheumatoid arthritis~Inflammation/Autoimmune disorders~Asthma~Multiple sclerosis~Thrombosis/Cardiac fibrosis~Vascular defects~Platelet defects/Platelet aggregation~Renal dysplasia~Crohn's disease~Colitis Macrophages from homozygous knockout rats demonstrate less Th1 response with less IFN-? secretion after simulation with PMAHomozygous knockout rats show decreased bone mass Homozygous knockout rats show elevated serum alkaline phosphotase levels Background Strain: Sprague-Dawley Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous T-box transcription factor (TBX21) is a member of the T-box protein family, which shares a common DNA-binding domain. TBX21 plays a critical role in Th1 cell differentiation through stimulation of IFN. Due to a hypersensitive immune system, the Tbx21 (-/-) rat model is useful for studies of acute and chronic human asthma, Crohn's disease, colitis, cancer metastasis, autoimmune disorders and inflammation. --
Produced in:
U.S.
Cryopreserved
Research use:
Rheumatoid arthritis, Inflammation/Autoimmune disorders, Asthma, Multiple sclerosis, Thrombosis/Cardiac fibrosis, Vascular defects, Platelet defects/Platelet aggregation, Renal dysplasia, Crohn's disease, Colitis
tdTomato reporter knockin rats HsdSage:LE-Rosa26tm1(tdTomato)Sage GEM rats Optogenetics~Expression of td~Tomato fluorescence when Cre-recombinase is introduced Background strain: Long Evans Hooded Availability: Live colony Zygosity genotype: Homozygous This model possesses the fluorophore tdTomato, sitting behind a floxed stop codon in the Rosa26 locus under control of the CAG promoter. By introducing Cre-recombinase through viral transduction or crossing with one of our Cre-driver rats, tdTomato fluorescence will be observed anywhere Cre- is expressed. The tdTomato Reporter rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with Cre-driver lines. --
Research use:
Neuroscience, Optogenetics, Expression of td, Tomato fluorescence when Cre-recombinase is introduced
TO outbred mice HsdOla:TO Outbred mice General purpose 3,6 % Exencephaly at birth Coat: Albino General purpose model Good reproductive performance Retinoic acid-induced asymmetric craniofacial growth and cleft palate --
Research use:
General purpose
Tph2-Cre knockin rats HsdSage:LE-Tph2tm1(T2A-Cre)Sage GEM rats Optogenetics~Expression/knockout of floxed genes Background strain: Long Evans Hooded Cre recombinase driven by endogenous Tph2 promoter No observed ectopic expression of cre Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC Availability: Live colony Zygosity genotype: Homozygous This model expresses cre-recombinase under the control of the endogenous Tryptophan Hydroxylase 2 (Tph2) promoter enabling specific expression in Tph2 positive serotonergic neurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the Tph2 gene. The Tph2-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. --
Research use:
Optogenetics, Expression/knockout of floxed genes
Trpv1 knockout rats HsdSage:SD-Trpv1tm1Sage GEM rats Analgesia~Cannabinoids~Nociception~Pain~Thermoregulation Background strain: Sprague Dawley Homozygous knockout rats exhibit complete loss of Trpv1 protein Trpv1 knockout rats show hyposensitivity to thermal pain via hot plate assay Availability: Cryopreserved as heterozygous embryos Zygosity: Heterozygous This model contains a biallelic deletion of the Trpv1 gene, encoding for the transient receptor potential cation channel subfamily V member 1. Capsaicin, the component in chili peppers that makes them hot, is an exogenous ligand for Trpv1. Trpv1 is also activated by heat. Trpv1 is a non-selective cation channel, activated by a range of stimuli including capsaicin, cannabinoids, and heat. Trpv1 activation results in the sensation of pain as well as the lowering of body temperature. Trpv1 antagonists are being pursued as potential novel analgesics. --
Research use:
Neuroscience, Analgesia, Cannabinoids, Nociception, Pain, Thermoregulation
Tyrosine Hydroxylase TH-Cre knockin rats HsdSage:SD-THtm1(IRES-Cre)Sage GEM rats Optogenetics~Expression/knockout of floxed genes~DREADD Background strain: Sprague Dawley No observed ectopic expression of cre Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC Availability: Live colony Zygosity genotype: Homozygous This model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Th. The TH-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. We have observed germline excision of floxed alleles in the offspring of female rats with both a floxed allele and at least one Cre allele. We recommend breedings between female rats with homozygous floxed alleles and male rats with both Cre and floxed alleles to obtain offspring that are Th-Cre postive and homozygous for a floxed locus. --
Research use:
Neuroscience, Optogenetics, Expression/knockout of floxed genes, DREADD
Vgat-Cre knockin rats HsdSage:LE-VGATtm1(IRES-Cre)Sage GEM rats Optogenetics~Expression/knockout of floxed genes Background strain: Long Evans Hooded Cre recombinase driven by endogenous Vgat promoter No observed ectopic expression of cre Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC Availability: Live colony Zygosity genotype: Homozygous This model expresses cre-recombinase under the control of the endogenous solute carrier family 32 member 1 (Vgat) promoter enabling specific expression in Vgat positive GABAergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of the Vgat gene. The Vgat-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. --
Research use:
Optogenetics, Expression/knockout of floxed genes
VIP-Cre knockin rats HsdSage:LE-VIPtm1(T2A-Cre)Sage GEM rats Optogenetics~Expression/knockout of floxed genes Background strain: Long Evans Hooded Cre recombinase driven by endogenous VIP promoter No observed ectopic expression of cre Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC Availability: Live Colony Zygosity genotype: Homozygous This model expresses cre-recombinase under the control of the endogenous vasoactive intestinal peptide (VIP) promoter enabling specific expression in VIP positive GABAergic interneurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the VIP gene. The VIP-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. --
Research use:
Optogenetics, Expression/knockout of floxed genes
Wistar Furth inbred rats WF/NHsd Inbred rats Transplantation~Immunology~Leukemia Coat: Albino Haplotype: RT1u Heteropyknotic Y chromosome cell marker Litter average: 5.5 Macrothrombocytopenia --
Research use:
Oncology, Transplantation, Immunology, Leukemia
Wistar Han® outbred rats RccHan:WIST Outbred rats Coat: Albino Docile disposition Global breeding and monitoring system - consistent research outcomes Litter average: 9.5 Longer survival - reduced costs, improved study outcomes Lower spontaneous tumor incidence - reduced research variables, improved animal welfare Smaller body size - less compound and cost --
Produced in:
U.S., U.K., The Netherlands
Research use:
Oncology, Toxicology, Aging, General studies, Teratology,
Wistar Kyoto inbred rats WKY/NHsd Inbred rats Immunology~Inbred, normotensive control for SHR rat Coat: Albino Normotensive control for SHR model --
Research use:
Immunology, Inbred, normotensive control for SHR rat
Wistar outbred rats Hsd:WI Outbred rats Oncology~Teratology~Nutrition~Aging Coat: Albino Docile disposition Litter average: 9.5 Spontaneous corneal degeneration --
Research use:
General studies, Oncology, Teratology, Nutrition, Aging
Wistar Unilever outbred rats HsdCpb:WU Outbred rats Oncology~Teratology~Nutrition~Aging~General purpose model Coat: Albino Disposition: Docile Good reproductive performance Incidentally hairloss Litter Average 10.5 --
Produced in:
The Netherlands
Research use:
Oncology, Teratology, Nutrition, Aging, General purpose model
Zucker obese rats HsdHlr:ZUCKER-Leprfa Mutant rats Adipocyte hypertrophy and hyperplasia Animals have not been selectively bred to induce hyperglycemia Coat: Black, brown, brown/white, black/white Exhibit obesity at 4 to 5 weeks of age fa is an autosomal-recessive mutation on chromosome 5 Hypercholesterolemia Hyperinsulinemia Hyperlipemic Hyperphagia Insulin resistant Leprfa/Lepr+heterozygotes do not show partial expression of fa phenotype Muscle atrophy --
Research use:
Obesity, Diabetes Type 2,
