Pinworms are an insidious and common threat to research utilizing laboratory mice and rats. This pest can adversely affect the reproducibility and reliability of research findings. Moreover, the parasitic load and adverse effects caused by pinworms can be even more pronounced in immunodeficient animals.
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Three recent studies made it clear: the R2G2® mouse is well suited for preclinical cancer studies that generate PDX, CDX and allograft models. The R2G2® mouse exhibited reduced radiosensitivity compared to NSGTM mice and tolerated estrogen supplementation and three standard-of-care chemotherapy drugs reasonably well. Moreover, as compared to other traditionally used immunodeficient strains, the R2G2® mouse had higher take rates and more favorable tumor growth.