Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as a mix of Heterozygous & WT embryos
Generated in conjunction with Autism Speaks, this knockout rat model contains a 176 kb deletion in the RNA binding protein, fox-1 homolog (Rbfox1) gene. Rbfox1 has been associated with the autism spectrum disorders and affects the expression of other autism-linked genes.
The Rbfox1 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.