p75NTR knockout rats: HsdSage:SD-Ngfrem1Sage GEM rats

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p75NTR knockout rats

HsdSage:SD-Ngfr^em1Sage

Strain

HsdSage:SD-Ngfr^em1Sage

Location

U.S. (Cryopreserved)

Strain

Location

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Cryopreserved as heterozygous embryos

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

11 base pair deletion in exon 2
Background strain: Sprague Dawley
Early stop codon in exon 3

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

This model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Along with TrkA, p75NTR is a receptor for the nerve growth receptor and is important in nociception. The p75NTR knockout rat is useful for pain research.

NGF dysfunction has been linked to neuropathic and osteoarthritic pain along with hyperalgesia. Inhibition of NGF, including inhibition of the p75NTR, is being pursued as a potential analgesic.

Origin: The p75NTR KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Model information sheet

Research use and related publications

Neuroscience
Analgesia
Neuronal apoptosis
Nociception
Pain

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