MeCP2 knockout rats: HsdSage:SD-Mecp2em1Sage GEM rats

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MeCP2 knockout rats

HsdSage:SD-Mecp2^em1Sage

Strain

HsdSage:SD-Mecp2^em1Sage

Location

U.S. (Cryopreserved)

Strain

Location

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Cryopreserved as heterozygous embryos

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background strain: Sprague Dawley
Hemi males are compromised at 6 weeks of age
Knockout rats exhibit complete loss of target protein as demonstrated by Western blot
Mutations in methyl-CpG-binding protein (MeCP2) result in Rett syndrome, a leading cause of intellectual disabilities in girls

Availability: Cryopreserved as heterozygous female embryos (X-Linked)
Zygosity: Heterozygous Females

This model contains a deletion of the methyl-CpG-binding protein (MeCP2)and is useful for the study of Rett syndrome. The gene is X-Linked. Mutations in MeCP2 have been linked to the development of Rett syndrome, a leading cause of intellectual disabilities in girls.

Origin: The MeCP2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Model information sheet

Research use and related publications

Neuroscience
Rett syndrome
Autism (ASD)
Cognition
Neuroscience
Rett Syndrome

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