Availability: Cryopreserved as heterozygous embryos
Homozygous Mrp2 null rats display compromised biliary excretion and hyperbilirubinemia. This results in accumulation of glutathione-conjugated drugs in the liver.
Mrp2 is expressed in the liver and functions in biliary transport. The gene's substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells. This model is useful for forumational, efficacy, tissue distribution, and DMPK assays