Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as heterozygous embryos
Developed in collaboration with The Michael J. Fox Foundation, this model is a double knockout that contains deletions of both the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2, as well as the Lrrk1 gene, encoding for the leucine-rich repeat kinase 1. Mutations in Lrrk2 are the most common monogenic cause of Parkinson's disease. This model is useful in understanding Lrrk biology.