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Bcrp knockout rat

LOCATION

Characteristics / Husbandry

  • Background strain: Sprague Dawley
  • Biallelic 588 bp deletion within Abcg2 gene
  • Homozygous knockouts display total loss of protein via Western blot
  • Increased oral bioavailability of BCRP-specific substrates

Availability: Live colony
Zygosity genotype: Homozygous

Bcrp plays a protective role in neurotoxicity by limiting the efflux of xenobiotics into the brain. Homozygous null rats demonstrate increased exposure in the brain and plasma when dosed with Bcrp-specific substrates.

Loss of function of Bcrp leads to improper transport of drugs across epithelial cells and increased bioavailability of Bcrp substrates. This model is useful for studying metabolism of xenobiotic compounds, tissue distribution, DMPK, efficacy, formulation, and blood brain barrier efflux.

ADMET
Neurotoxicology
DMPK efflux assay
Formulation blood brain barrier efflux
Drug-drug interactions
Tissue distribution
Efficacy assay
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The Bcrp KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.