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Oct2 knockout rats

HsdSage:SD-Slc22a2^tm1Sage

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HsdSage:SD-Slc22a2^tm1Sage

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Oct1 (-/-) rats have increased exposure to specific substrates

Availability: Live colony
Zygosity: Heterozygous

A related model Oct1 (-/-) rats have increased exposure to specific substrates

This model contains a biallelic deletion within the Slc22a2 solute carrier family 22 (organic cation transporter), member 2, encoding for the basolateral hepatocyte uptake transporter OCT2.

Oct2 is involved in disposition and excretion through its role in xenobiotic uptake in the basolateral membrane of the liver. Polymorphisms within the gene also have clinical relevance - making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver.

Origin: The Oct2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

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Model information sheet

Research use and related publications

Drug-drug interactions
Drug metabolism
Drug transport
Hepatotoxicity

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Oct2 knockout rats

HsdSage:SD-Slc22a2^tm1Sage

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Oct2 knockout rats

HsdSage:SD-Slc22a2tm1Sage

Available regions:

2020 Product guide

Meet Brad Gien

Scientific Insights

Subscribe to updates from Envigo

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Research models

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Teklad diet, bedding and enrichment

Resources

HsdSage:SD-Slc22a2^tm1Sage