Availability: Cryopreserved as heterozygous embryos
This model carries a bi-allelic deletion of the amyloid precursor protein (APP) gene. APP can be cleaved by the beta and gamma secretases, forming beta amyloid. Beta amyloid can self-aggregate to form amyloid plaques, one of the hallmarks of Alzheimer's disease.
The App Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.