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Rag2-Il2rg Double Knockout Mice (R2G2^®)

B6;129-Rag2^tm1FwaII2rg^tm1Rsky/DwlHsd

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B6;129-Rag2^tm1FwaII2rg^tm1Rsky/DwlHsd

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Strains

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Coat white-bellied, light chinchilla (light tan)
Common gamma chain gene (II2rg) interrupted
Decreased dendritic cells
Decreased macrophage cells
Decreased neutrophils
Deficient in T and B cells
Lacks functional receptors for IL-2, IL-4, IL-7, IL-9 and IL-15
Lacks NK cells
Recombination activating gene 2 (Rag2) interrupted
Severe lymphocyte development impairment

Origin:

The R2G2 model is a double knockout mouse with an ultra immunodeficient phenotype. The model was created by backcrossing the IL2RG (common gamma chain) mutation on to a mixed background mouse (C57BL/6 and129 mix) with a mutation in Rag2. The recombination activating gene 2 (Rag2) interruption causes a deficiency in T and B cells. The Common gamma chain gene (IL2RG) interruption results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9 and IL-15.

Envigo acquired from Fox Chase Cancer Center in 2016, where the model had been maintained since 2005. The model is a white-bellied, light chinchilla (light tan).

United States - 265I - Greenfield, IN

Download growth curve

r2g2-growth-curve-mar2017

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Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

Female, Academic Order code: 021 - US

Description	Price	Currency
3-4 weeks	98.70	USD
4-5 weeks	98.70	USD
5-6 weeks	101.85	USD
6-7 weeks	105.00	USD
7-8 weeks	108.15	USD
Over 8 weeks, add per week	5.00	USD

Female, Commercial Order code: 021 - US

Description	Price	Currency
3-4 weeks	146.80	USD
4-5 weeks	146.80	USD
5-6 weeks	149.85	USD
6-7 weeks	152.95	USD
7-8 weeks	156.05	USD
Over 8 weeks, add per week	4.65	USD

Male, Academic Order code: 021 - US

Description	Price	Currency
3-4 weeks	93.20	USD
4-5 weeks	93.20	USD
5-6 weeks	99.10	USD
6-7 weeks	102.35	USD
7-8 weeks	105.55	USD
Over 8 weeks, add per week	5.00	USD

Male, Commercial Order code: 021 - US

Description	Price	Currency
3-4 weeks	139.05	USD
4-5 weeks	139.05	USD
5-6 weeks	142.15	USD
6-7 weeks	145.25	USD
7-8 weeks	148.30	USD
Over 8 weeks, add per week	4.65	USD

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Rag2-Il2rg Double Knockout Mice (R2G2^®)

B6;129-Rag2^tm1FwaII2rg^tm1Rsky/DwlHsd

Available regions:

Female, Academic Order code: 021 - US

Female, Commercial Order code: 021 - US

Male, Academic Order code: 021 - US

Male, Commercial Order code: 021 - US

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Rag2-Il2rg Double Knockout Mice (R2G2®)

B6;129-Rag2tm1FwaII2rgtm1Rsky/DwlHsd

Available regions:

Female, Academic Order code: 021 - US

Female, Commercial Order code: 021 - US

Male, Academic Order code: 021 - US

Male, Commercial Order code: 021 - US

2020 Product guide

Meet Brad Gien

Scientific Insights

Subscribe to updates from Envigo

About Envigo

Research models

Research services

Teklad diet, bedding and enrichment

Resources

Rag2-Il2rg Double Knockout Mice (R2G2^®)

B6;129-Rag2^tm1FwaII2rg^tm1Rsky/DwlHsd