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5Ht3a-Cre knockin rats

Produced in:

U.S. Cryopreserved

Research use:

Cre Tool for conditional expression or deletion in 5HT3a+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

AHR knockout rats

Produced in:

U.S.

Research use:

ADMET, Cholestasis, Cytochrome p450 pathways, Drug metabolism, Hepatotoxicity, Xenobiotic

Alpha-Synuclein A53T SNCA knockin rats

Produced in:

U.S.

Research use:

Dopaminergic cell toxicity, Neuroscience, Parkinson's disease

Alpha-Synuclein-SNCA knockout rats

Produced in:

U.S.

Research use:

Dopaminergic cell toxicity, Neuroscience, Parkinson's disease

ApoE knockout rats

Produced in:

U.S.

Research use:

Atherosclerosis, Neuroscience, Alzheimer's disease, Cardiovascular, Neurodegenerative diseases, Neuroscience

App knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Alzheimer's disease, Dementia, Memory loss, Neurodegeneration, Neuroscience, Synaptic formation and repair

Bcrp knockout rats

Produced in:

U.S.

Research use:

ADMET, Tissue distribution, DMPK efflux assay, Drug-drug interactions, Drug metabolism, Drug transporter, Efficacy assay, Formulation blood brain barrier efflux, Neuroscience, Tissue distribution

BDNF knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Neuroscience, Alzheimer's disease, Depression, Huntington's disease, Memory loss, Nerve growth and development, Neuroscience, Pain, Post-traumatic stress disorder, Schizophrenia

BSEP knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Cholestasis, Drug-drug interactions, Drug-induced cholestasis (DIC), Drug metabolism, Drug transporter

Cacna1c knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Neurodegeneration, Social behavior, Alzheimer's disease, Autism (ASD), Dementia, Memory loss, Neuroscience, Synaptic formation and repair

CamKIIa-Cre knockin rats

Produced in:

U.S.

Research use:

Cre Tool for conditional expression or deletion in CamKIIa+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

CAR knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Cytochrome p450 pathways, Cholestasis, Hepatotoxicity, Drug metabolism, Xenobiotic

CFTR knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Lung Disease, Chloride transport, Cystic Fibrosis, Lung Disease, Thiocyanide transport

CHD8 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Autism (ASD), Neuroscience

Chrna7 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Epilepsy, Neuronal growth and transport studies, Neuroscience, Schizophrenia

Cntnap2 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Autism, Neuroscience, Cell adhesion, Language disorders, Synaptic Plasticity

Cox1 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Asthma, Colitis, Crohn's disease, Immunology, Multiple sclerosis, Platelet defects/Platelet aggregation, Renal dysplasia, Rheumatoid arthritis, Inflammation/Autoimmune disorders, Thrombosis/Cardiac fibrosis, Vascular defects

Cox2 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Asthma, Colitis, Crohn's disease, Immunology, Inflammation/Autoimmune disorders, Multiple sclerosis, Platelet defects/Platelet aggregation, Renal dysplasia, Rheumatoid arthritis, Thrombosis/Cardiac fibrosis, Vascular defects

Disc1 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Bipolar disorder, Neuronal growth and transport studies, Neuroscience, Schizophrenia

Dopamine Transporter DAT-Cre knockin rats

Produced in:

U.S. Cryopreserved

Research use:

Neuroscience, Cre Tool for conditional expession or deletion in dopaminergic neurons, DREDD, Expression/knockout of floxed genes, Optogenetics

Dopamine Transporter DAT-Cre knockin rats

Produced in:

U.S.

Research use:

Neuroscience, Cre Tool for conditional expession or deletion in dopaminergic neurons, DREDD, Expression/knockout of floxed genes, Optogenetics

Faah knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Analgesia, Cannabinoids, Neuroscience, Nociception, Pain

Fmr1 knockout rats

Produced in:

U.S.

Research use:

Autism, Fragile x syndrome, Neuroscience, Autism (ASD), Fragile X syndrome, Neuroscience

Gabrb3 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Autism (ASD), Epilepsy, Neuroscience, Prader-Willi syndrome

hApoE2 knockin rats

Produced in:

U.S.

Research use:

Alzheimer's disease, Dopaminergic cell toxicity, Neuroscience

hApoE3 knockin rats

Produced in:

U.S.

Research use:

Alzheimer's disease, Dopaminergic cell toxicity, Neuroscience

hApoE4 knockin rats

Produced in:

U.S.

Research use:

Alzheimer's disease, Alzheimer's disease, Neurodegenerative diseases, Neuroscience

Ldlr knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Cardiovascular, Artery disease, Atherogenesis, Atherosclerosis- Cholesterol transportation, Hypertension, Insulin resistant, Lipoprotein, Metabolism (Triglyceride - Cholesterol), Obesity, Type II diabetes

Leptin knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Artery disease, Atherogenesis, Atherosclerosis, Cardiovascular, Diabetes, HypertensionInsulin resistance, Lipoprotein/Cholesterol transportation, Metabolism (Triglyceride/Cholesterol), Obesity, Type II diabetes

Lgals1 (Gal1) knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Asthma, Colitis, Crohn's disease, Immunology, Inflammation/Autoimmune disorders, Multiple sclerosis, Oncology, Platelet defects/Platelet aggregation, Renal dysplasia, Rheumatoid arthritis, Thrombosis/Cardiac fibrosis, Vascular defects

Lrrk1 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Neuronal apoptosis, Neuroscience, Parkinson's disease

Lrrk1-Lrrk2 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Neuronal apoptosis, Neuroscience, Parkinson's disease

Lrrk2 knockout rats

Produced in:

U.S.

Research use:

Neuroscience, Neuronal apoptosis, Parkinson's disease

Mdr1a knockout rats

Produced in:

U.S.

Research use:

ADMET, Blood brain barrier efflux, DMPK assay, Drug metabolism, Drug resistance, Drug transporter, Efficacy, Formulation drug-drug interactions, Neurotoxicology, PK-PD efflux assay

Mdr1a-1b knockout rats

Produced in:

U.S.

Research use:

Drug-drug interactions, ADMET, Blood brain barrier efflux, DMPK assay, Drug metabolism, Drug resistance, Drug transporter, Efficacy, Formulation drug-drug interactions, Neurotoxicology, PK-PD efflux assay

Mdr1a-Bcrp knockout rats

Produced in:

U.S.

Research use:

ADMET, Blood brain barrier efflux, DMPK assay, Drug metabolism, Drug resistance, Drug transporter, Efficacy, Formulation drug-drug interactions, Neurotoxicology, PK-PD efflux assay

MeCP2 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Neuroscience, Rett syndrome, Autism (ASD), Cognition, Neuroscience, Rett Syndrome

Met knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Autism (ASD), Autoimmune disorders, Neuroscience, Synaptic Plasticity

mGluR5 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Neuroscience, Anxiety, Autism (ASD), Cognition, Fragile X syndrome, Pain, Schizophrenia

Mrp1 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Drug metabolism, Drug resistance, Drug transporter, Studying excretion pathways in cancer

Mrp2 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Tissue distribution, DMPKPK/PDFormulation, Drug transporter, Dubin-Johnson syndrome, Efficacy Drug-drug interactions, Efflux assays, Tissue distribution

Neurexin1-Nrxn1 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Autism, Neuroscience, Schizophrenia, Synaptic Plasticity

Neuroligin 3 (Nlgn3) knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Neuroscience, Asperger's syndrome, Autism (ASD), Synaptic Plasticity

Oat1 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Drug-drug interactions, Drug metabolism, Drug transporter, Hepatotoxicity

Oat3 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Drug-drug interactions, Drug metabolism, Drug transporter, Hepatotoxicity

Oct1 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Drug-drug interactions, Drug metabolism, Drug transporter, Hepatotoxicity

Oct2 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Drug-drug interactions, Drug metabolism, Drug transporter, Hepatotoxicity

Oprm1 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Addiction, Analgesia, Neuroscience, Nociception, Pain

p53 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Autoimmune disease, Cancer, Hematopoiesis, Infectious disease, Oncology, Vaccine development, Xenografts

p75NTR knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Neuroscience, Analgesia, Neuronal apoptosis, Nociception, Pain

Park2 Parkin knockout rats

Produced in:

U.S.

Research use:

Neuroscience, Dopaminergic cell toxicity, Parkinson's disease

Park7 DJ-1 knockout rats

Produced in:

U.S.

Research use:

Neuroscience, Dopaminergic cell toxicity, Parkinson's disease

Parvalbumin-Cre knockin rats

Produced in:

U.S.

Research use:

Neuroscience, Cre Tool for conditional expession or deletion in PV+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Pde4b knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Bipolar disorder, Neuronal growth and transport studies, Neuroscience, Schizophrenia

Pink1 knockout rats (Park6)

Produced in:

U.S.

Research use:

Neuroscience, Parkinson's disease, Stress-induced neurological dysfunction, Parkinson's disease

Ppara knockout rats

Produced in:

U.S.

Research use:

ADMET, Autoimmune disorders, Cell proliferation, Drug metabolism, Diabetes, Immunology, Inflammation, Lipid metabolism, Obesity, Wound healing, Xenobiotic

Prkdc knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Immunology, Cancer metastasis, Oncology, Tumor cell growth, Xenograft

Pten knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Autism, Cancer, Neuroscience, Oncology

PXR knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Cholestasis, Cytochrome p450 pathways, Drug metabolism, Hepatotoxicity, Xenobiotic

PXR-CAR knockout rats

Produced in:

U.S.

Research use:

ADMET, Cholestasis, Cytochrome p450 pathways, Drug metabolism, Hepatotoxicity, Xenobiotic

PXR/CAR/AHR knockout rats

Produced in:

U.S. Cryopreserved

Research use:

ADMET, Cholestasis, Cytochrome p450 pathways, Drug metabolism, Hepatotoxicity, Xenobiotic

Rag1 knockout rats (Fischer 344)

Produced in:

U.S. Cryopreserved

Research use:

Cancer metastasis, Immunology, Inflammation/Autoimmune disorders, Oncology, Thrombosis/Cardiac fibrosis, Vaccine development, Xenograft

Rag1 knockout rats (Sprague Dawley)

Produced in:

U.S. Cryopreserved

Research use:

Cancer metastasis, Hematopoieses, Immunology, Inflammation/Autoimmune disorders, Infectious disease, Oncology, Thrombosis/Cardiac fibrosis, Vaccine development, Vascular defects, Xenograft

Rag2 knockout rats (Fischer 344)

Produced in:

U.S. Cryopreserved

Research use:

Cancer metastasis, Inflammation/Autoimmune disorders, Thrombosis/Cardiac fibrosis, Vaccine development, Vascular defects, Xenograft

Rag2 knockout rats (Sprague Dawley)

Produced in:

U.S.

Research use:

Infectious disease, Oncology, Vaccines, Cancer metastasis, Immunology, Inflammation/Autoimmune disorders, Hematopoieses, Thrombosis/Cardiac fibrosis, Vascular defects, Xenograft

Rbfox1 knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Autism (ASD), Neurodegenerative Disorders, Neuroscience

Sst-Cre knockin rats

Produced in:

U.S.

Research use:

Cre Tool for conditional expession or deletion in SST+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Tbx21 (T-beta) knockout rats

Produced in:

U.S. Cryopreserved

Research use:

Asthma, Colitis, Crohn's disease, Immunology, Inflammation/Autoimmune disorders, Multiple sclerosis, Oncology, Platelet defects/Platelet aggregation, Renal dysplasia, Rheumatoid arthritis, Thrombosis/Cardiac fibrosis, Vascular defects

tdTomato reporter knockin rats

Produced in:

U.S.

Research use:

Neuroscience, Tomato fluorescence, Expression of td, Optogenetics, Tomato fluorescence when Cre-recombinase is introduced

Tph2-Cre knockin rats

Produced in:

U.S.

Research use:

Cre Tool for conditional expession or deletion in Tph2+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

Trpv1 knockout rats

Produced in:

U.S.

Research use:

Neuroscience, Analgesia, Cannabinoids, Nociception, Pain, Thermoregulation

Tyrosine Hydroxylase TH-Cre knockin rats

Produced in:

U.S.

Research use:

Neuroscience, Cre Tool for conditional expession or deletion in Th+ neurons, DREADD, Expression/knockout of floxed genes, Optogenetics

Vgat-Cre knockin rats

Produced in:

U.S.

Research use:

Cre Tool for conditional expession or deletion in VGAT+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

VIP-Cre knockin rats

Produced in:

U.S.

Research use:

Cre Tool for conditional expession or deletion in VIP+ neurons, Expression/knockout of floxed genes, Neuroscience, Optogenetics

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Paul<br>Knepley, DVM, Attending Veterinarian

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Knepley, DVM

Attending Veterinarian

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