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Zucker obese rats

LOCATION

Characteristics / Husbandry

  • Hyperphagia
  • Hyperinsulinemia
  • Coat: Black, brown, brown/white, black/white
  • fa is an autosomal-recessive mutation on chromosome 5
  • Exhibit obesity at 4 to 5 weeks of age
  • Animals have not been selectively bred to induce hyperglycemia
  • Insulin resistant
  • Adipocyte hypertrophy and hyperplasia
  • Muscle atrophy
  • Hyperlipemic
  • Hypercholesterolemia
  • Leprfa/Lepr+heterozygotes do not show partial expression of fa phenotype
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Derived from a colony obtained in 1992 from Hoffmann-la-Roche, Nutley, New Jersey.

Order Code: 194(fa)/195(fa/+)

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