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VIP-Cre knockin rat

LOCATIONS

Characteristics / Husbandry

  • Background strain: Long Evans Hooded
  • Cre recombinase driven by endogenous VIP promoter
  • No observed ectopic expression of cre
  • Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC

Availability: Live Colony
Zygosity genotype: Homozygous

This model expresses cre-recombinase under the control of the endogenous vasoactive intestinal peptide (VIP) promoter enabling specific expression in VIP positive GABAergic interneurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the VIP gene. The VIP-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.

Research Use & Related Publications
Optogenetics
Expression/knockout of floxed genes
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The VIP-Cre KI rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.