Lrrk2 knockout rat


Characteristics / Husbandry

  • Background strain: Long Evans Hooded
  • Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
  • Lrrk2 knockout rats are significantly larger than wild type controls
  • Lrrk2 knockout rats display dark kidneys, similar to observations made in Lrrk2 knockout mice

Availability: Live colony
Zygosity genotype: Homozygous

Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2. Mutations in Lrrk2 are the most common monogenic cause of Parkinson's disease. This model is useful in understanding Lrrk2 biology.

Lrrk2 mutations account for 5-6% of familial Parkinson's dieases and 1-3% in sporadic PD. Collectively, these mutations result in the most common cause of PD, making this an important model for the study of Parkinson's disease.

Parkinson's disease
Neuronal apoptosis
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The Lrrk2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.