Characteristics / Husbandry

  • An expansion of CGG trinucleotide repeat in Fmr1 has been implicated in Fragile X syndrome
  • Background strain: Sprague Dawley
  • Homozygous knockout rats display total loss of protein via Western blot
  • Preliminary results suggest Fmr1 knockout rats possess perseverative chewing behavior and decreased juvenile play
  • This gene is X-linked
  • This model was created in collaboration with Autism Speaks and underwent phenotypic characterization by Dr. Richard Paylor.

Availability: Live colony
Zygosity genotype: Homozygous (Females) / Hemizygous (Males)

This model contains a deletion of the Fragile X mental retardation 1 gene (Fmr1). Mutations in Fmr1 result in Fragile X syndrome, the leading monogenic cause of autism, making this rat useful for the study of both Fragile X syndrome and autism.

The X-linked gene Fmr1 produces the fragile X metal retardation protein, or FMRP. FMRP is essential for normal mental development. An expansion of the trinucleotide CGG repeat in the Fmr1 gene is responsible for fragile X syndrome, a syndrome characterized by autism and mental disability.

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