Alpha-Synuclein-SNCA knockout rat


Characteristics / Husbandry

  • Background strain: Sprague Dawley

Availability: Live colony
Zygosity genotype: Homozygous

Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the endogenous rat SNCA gene, encoding the alpha-synuclein protein. This model was generated using the CRISPR/Cas9 genome targeting strategy. Mutations and multiplications of the SNCA gene have been linked to early-onset Parkinson’s disease (PD), making this model useful for understanding alpha-synuclein biology and PD pathogenesis.

Research Use & Related Publications
Parkinson's disease
Dopaminergic cell toxicity
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The Alpha-Synuclein SNCA KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.