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Characteristics / Husbandry

  • Coat: Albino
  • Autosomal-recessive, single-nucleotide polymorphism within Prkdc gene on chromosome 16
  • Severe combined immunodeficiencyaffecting T- and B-cell development
  • Natural Killer (NK) cell, macrophage, and granulocyte cell numbers and function are normal
  • As SCID mice age, a variable percentage become 'leaky' from the spontaneous development of functional T and B lymphocytes
  • Highly susceptible to opportunistic viral and bacterial infection
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Harlan acquired from the Fox Chase Cancer Center, Philadelphia, Pennsylvania, in 1991. Harlan became Envigo in 2015.

Order Code: 883

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