Rag2-Il2rg Double Knockout Mouse (R2G2®)


Characteristics / Husbandry

  • Recombination activating gene 2 (Rag2) interrupted
  • Common gamma chain gene (II2rg) interrupted
  • Lacks functional receptors for IL-2, IL-4, IL-7, IL-9 and IL-15
  • Coat white-bellied, light chinchilla (light tan)
  • Severe lymphocyte development impairment
  • Deficient in T cells
  • Deficient in B cells
  • Lacks NK cells
  • Decreased macrophage cells
  • Decreased dendritic cells
  • Decreased neutrophils
Tumor Biology
Infectious disease
Cancer cell transplantation
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The R2G2 model is a double knockout mouse with an ultra immunodeficient phenotype.  The model was created by backcrossing the IL2RG (common gamma chain) mutation on to a mixed background mouse (C57BL/6 and129 mix) with a mutation in Rag2.  The recombination activating gene 2 (Rag2) interruption causes a deficiency in T and B cells.  The Common gamma chain gene (IL2RG) interruption results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9 and IL-15.

Envigo acquired from Fox Chase Cancer Center in 2016, where the model had been maintained since 2005.  The model is a white-bellied, light chinchilla (light tan).

Order Code: 021

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