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Obese (ob/ob) mice Related Publications

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Adar, T., Ben Ya'acov, A., Lalazar, G., Lichtenstein, Y., Nahman, D., Mizrahi, M., . . . Ilan, Y. (2012). Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells. Clinical and Experimental Immunology, 167(2), 252-260. doi:10.1111/j.1365-2249.2011.04511.x [doi] Read Publication

Chung, H. K., Kim, Y. K., Park, J. H., Ryu, M. J., Chang, J. Y., Hwang, J. H., . . . Shong, M. (2015). The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation. Liver International : Official Journal of the International Association for the Study of the Liver, 35(4), 1341-1353. doi:10.1111/liv.12741 [doi] Read Publication

Church, S. J., Begley, P., Kureishy, N., McHarg, S., Bishop, P. N., Bechtold, D. A., . . . Cooper, G. J. (2015). Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease. Biochemical and Biophysical Research Communications, 460(3), 549-554. doi:10.1016/j.bbrc.2015.03.067 [doi] Read Publication

Raptis, D. A., Fischer, M. A., Graf, R., Nanz, D., Weber, A., Moritz, W., . . . Clavien, P. A. (2012). MRI: The new reference standard in quantifying hepatic steatosis? Gut, 61(1), 117-127. doi:10.1136/gutjnl-2011-300155 [doi] Read Publication

Tang, Y., & Chen, A. (2014). Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling. Laboratory Investigation; a Journal of Technical Methods and Pathology, 94(5), 503-516. doi:10.1038/labinvest.2014.42 [doi] Read Publication

Wang, X., West, J. A., Murray, A. J., & Griffin, J. L. (2015). Comprehensive metabolic profiling of age-related mitochondrial dysfunction in the high-fat-fed ob/ob mouse heart. Journal of Proteome Research, 14(7), 2849-2862. doi:10.1021/acs.jproteome.5b00128 [doi] Read Publication

Agabiti-Rosei, C., De Ciuceis, C., Rossini, C., Porteri, E., Rodella, L. F., Withers, S. B., . . . Rezzani, R. (2014). Anticontractile activity of perivascular fat in obese mice and the effect of long-term treatment with melatonin. Journal of Hypertension, 32(6), 1264-1274. doi:10.1097/HJH.0000000000000178 [doi] Read Publication

Eljaafari, A., Robert, M., Chehimi, M., Chanon, S., Durand, C., Vial, G., . . . Pirola, L. (2015). Adipose tissue-derived stem cells from obese subjects contribute to inflammation and reduced insulin response in adipocytes through differential regulation of the Th1/Th17 balance and monocyte activation. Diabetes, 64(7), 2477-2488. doi:10.2337/db15-0162 [doi] Read Publication

Gabriel, T. L., Tol, M. J., Ottenhof, R., van Roomen, C., Aten, J., Claessen, N., . . . van Eijk, M. (2014). Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent gpnmb induction. Diabetes, 63(10), 3310-3323. doi:10.2337/db13-1720 [doi] Read Publication

Lustig, Y., Barhod, E., Ashwal-Fluss, R., Gordin, R., Shomron, N., Baruch-Umansky, K., . . . Kanety, H. (2014). RNA-binding protein PTB and microRNA-221 coregulate AdipoR1 translation and adiponectin signaling. Diabetes, 63(2), 433-445. doi:10.2337/db13-1032 [doi] Read Publication

Rodriguez, A., Becerril, S., Mendez-Gimenez, L., Ramirez, B., Sainz, N., Catalan, V., . . . Fruhbeck, G. (2015). Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice. International Journal of Obesity (2005), 39(3), 397-407. doi:10.1038/ijo.2014.166 [doi] Read Publication

Al-Romaiyan, A., King, A. J., Persaud, S. J., & Jones, P. M. (2013). A novel extract of gymnema sylvestre improves glucose tolerance in vivo and stimulates insulin secretion and synthesis in vitro. Phytotherapy Research : PTR, 27(7), 1006-1011. doi:10.1002/ptr.4815 [doi] Read Publication

Giannulis, I., Mondini, E., Cinti, F., Frontini, A., Murano, I., Barazzoni, R., . . . Cinti, S. (2014). Increased density of inhibitory noradrenergic parenchymal nerve fibers in hypertrophic islets of langerhans of obese mice. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 24(4), 384-392. doi:10.1016/j.numecd.2013.09.006 [doi] Read Publication

Hauge-Evans, A. C., Reers, C., Kerby, A., Franklin, Z., Amisten, S., King, A. J., . . . Jones, P. M. (2014). Effect of hyperglycaemia on muscarinic M3 receptor expression and secretory sensitivity to cholinergic receptor activation in islets. Diabetes, Obesity & Metabolism, 16(10), 947-956. doi:10.1111/dom.12301 [doi] Read Publication

Irles, E., Neco, P., Lluesma, M., Villar-Pazos, S., Santos-Silva, J. C., Vettorazzi, J. F., . . . Quesada, I. (2015). Enhanced glucose-induced intracellular signaling promotes insulin hypersecretion: Pancreatic beta-cell functional adaptations in a model of genetic obesity and prediabetes. Molecular and Cellular Endocrinology, 404, 46-55. doi:10.1016/j.mce.2015.01.033 [doi] Read Publication

Irwin, N., Frizelle, P., Montgomery, I. A., Moffett, R. C., O'Harte, F. P., & Flatt, P. R. (2012). Beneficial effects of the novel cholecystokinin agonist (pGlu-gln)-CCK-8 in mouse models of obesity/diabetes. Diabetologia, 55(10), 2747-2758. doi:10.1007/s00125-012-2654-6 [doi] Read Publication

Liu, B., Hassan, Z., Amisten, S., King, A. J., Bowe, J. E., Huang, G. C., . . . Persaud, S. J. (2013). The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis. Diabetologia, 56(11), 2467-2476. doi:10.1007/s00125-013-3022-x [doi] Read Publication

Martagon, A. J., Lin, J. Z., Cimini, S. L., Webb, P., & Phillips, K. J. (2015). The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PloS One, 10(4), e0122987. doi:10.1371/journal.pone.0122987 [doi] Read Publication

Mechlovich, D., Amit, T., Bar-Am, O., Weinreb, O., & Youdim, M. B. (2014). Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus. British Journal of Pharmacology, 171(24), 5636-5649. doi:10.1111/bph.12862 [doi] Read Publication

Ngala, R. A., Zaibi, M. S., Langlands, K., Stocker, C. J., Arch, J. R., & Cawthorne, M. A. (2014). Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3. Peerj, 2, e614. doi:10.7717/peerj.614 [doi] Read Publication

Patterson, S., de Kort, M., Irwin, N., Moffett, R. C., Dokter, W. H., Bos, E. S., . . . Flatt, P. R. (2015). Pharmacological characterization and antidiabetic activity of a long-acting glucagon-like peptide-1 analogue conjugated to an antithrombin III-binding pentasaccharide. Diabetes, Obesity & Metabolism, 17(8), 760-770. doi:10.1111/dom.12483 [doi] Read Publication

Rieusset, J., Chauvin, M. A., Durand, A., Bravard, A., Laugerette, F., Michalski, M. C., & Vidal, H. (2012). Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance. Biochemical and Biophysical Research Communications, 417(1), 439-445. doi:10.1016/j.bbrc.2011.11.135 [doi] Read Publication

Tubbs, E., Theurey, P., Vial, G., Bendridi, N., Bravard, A., Chauvin, M. A., . . . Rieusset, J. (2014). Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance. Diabetes, 63(10), 3279-3294. doi:10.2337/db13-1751 [doi] Read Publication

Wargent, E. T., Zaibi, M. S., Silvestri, C., Hislop, D. C., Stocker, C. J., Stott, C. G., . . . Cawthorne, M. A. (2013). The cannabinoid delta(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity. Nutrition & Diabetes, 3, e68. doi:10.1038/nutd.2013.9 [doi] Read Publication

Zuellig, R. A., Hornemann, T., Othman, A., Hehl, A. B., Bode, H., Guntert, T., . . . Sonda, S. (2014). Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells. Diabetes, 63(4), 1326-1339. doi:10.2337/db13-1042 [doi] Read Publication

Bastianini, S., Berteotti, C., Gabrielli, A., Del Vecchio, F., Amici, R., Alexandre, C., . . . Zoccoli, G. (2014). SCOPRISM: A new algorithm for automatic sleep scoring in mice. Journal of Neuroscience Methods, 235, 277-284. doi:10.1016/j.jneumeth.2014.07.018 [doi] Read Publication

Favero, G., Lonati, C., Giugno, L., Castrezzati, S., Rodella, L. F., & Rezzani, R. (2013). Obesity-related dysfunction of the aorta and prevention by melatonin treatment in ob/ob mice. Acta Histochemica, 115(8), 783-788. doi:10.1016/j.acthis.2013.02.014 [doi] Read Publication

Feingold, K. R., Grunfeld, C., Heuer, J. G., Gupta, A., Cramer, M., Zhang, T., . . . Kharitonenkov, A. (2012). FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis. Endocrinology, 153(6), 2689-2700. doi:10.1210/en.2011-1496 [doi] Read Publication

Procaccini, C., De Rosa, V., Galgani, M., Carbone, F., Cassano, S., Greco, D., . . . Matarese, G. (2012). Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. Journal of Immunology (Baltimore, Md.: 1950), 189(6), 2941-2953. doi:10.4049/jimmunol.1200935 [doi] Read Publication

Rezzani, R., Rodella, L. F., Favero, G., Damiani, G., Paganelli, C., & Reiter, R. J. (2014). Attenuation of ultraviolet A-induced alterations in NIH3T3 dermal fibroblasts by melatonin. The British Journal of Dermatology, 170(2), 382-391. doi:10.1111/bjd.12622 [doi] Read Publication

Shabat, Y., Lichtenstein, Y., Zolotarov, L., Ben Ya'acov, A., & Ilan, Y. (2013). Hepatoprotective effect of DT56a is associated with changes in natural killer T cells and regulatory T cells. Journal of Digestive Diseases, 14(2), 84-92. doi:10.1111/1751-2980.12003 [doi] Read Publication

Reynolds, C. M., Toomey, S., McBride, R., McMonagle, J., Morine, M. J., Belton, O., . . . Roche, H. M. (2013). Divergent effects of a CLA-enriched beef diet on metabolic health in ApoE-/- and ob/ob mice. The Journal of Nutritional Biochemistry, 24(2), 401-411. doi:10.1016/j.jnutbio.2011.12.006 [doi] Read Publication