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Obese (ob/ob) mice


LOCATIONS

Characteristics / Husbandry

  • Coat: Black
  • Lepob autosomal-recessive mutation on chromosome 6
  • Obesity expressed at 4 to 5 weeks of age
  • Hyperphagia
  • Hyperinsulinemia
  • Moderate transient hyperglycemia
  • Hyperlipemia
  • Leptin protein deficient
  • Insulin-resistant
  • Defective body temperature regulation
  • Adipocyte hyperplasia
  • Sterile homozygous females
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Reaching your goals in obesity studies can be a challenge or a success depending on the reliability of your research models. The Lepob mutation was discovered in 1949 in an outbred mouse stock and was subsequently transferred to a C57BL/6 background. This model has since been well characterized as a model of obesity, exhibiting commonly published metabolic symptoms including hyperinsulinemia and hyperphagia.

Mutation backcrossed onto the C57BL/6J strain at The Jackson Laboratories, Bar Harbor, Maine, in the 1950’s.  Acquired by the Laboratory Animals Centre, Carshalton, United Kingdom, in 1974.  To Olac, United Kingdom, in 1978. To Harlan Laboratories, in 2001. Harlan became Envigo in 2015.

Order Code: 177(ob)/178(lean)

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