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NOD.SCID mice


LOCATIONS

Characteristics / Husbandry

  • Coat: Albino
  • Highly susceptible to opportunistic viral and bacterial infection
  • Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16
  • Severe combined immunodeficiency affecting T- and B-lymphocyte development
  • Natural Killer (NK) cell, macrophage and granulocyte numbers and function are reduced
  • As SCID mice age, a variable percentage become 'leaky' from spontaneous development of functional T- and B-lymphocytes
  • Development of autoimmune diabetes does not occur due to severe combined immunodeficiency
  • Spontaneous thymic lymphomas
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Received by National Cancer Institute, Frederick, Maryland in 2004 from National Institutes of Health, Bethesda, Maryland. Harlan Laboratories acquired from National Cancer Institute in 2006. Harlan became Envigo in 2015.

Order Code: 170

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