Athymic nude mice

Characteristics / Husbandry

  • Coat: Albino
  • Litter Average: 7
  • The nu allele on chromosome 11 is an autosomal recessive mutation
  • Dysfunctional rudimentary thymus
  • Phenotypically hairless (sparse, intermittent hair growth possible)
  • T-cell deficient
  • B-cells function normal
  • No generation of cytotoxic effector cells
  • No graft versus host response
  • Foxn1nu/Foxn1+ heterogygotes do not show partial expression of the nu phenotype
Gene Therapy
Tumor Cell Growth
General Studies
Autoimmune Disease
Antibody production
Sentinel model - Heterozygous Hsd:Athymic Nude-Foxn1nu/Foxn1+
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Derived from a nucleus colony obtained from the National Cancer Institute, Frederick, Maryland.

This immunodeficient model was originally thought to be a Balb/c congenic, but was later reported by NCI to be outbred.

Order Code: 069(nu)/070(nu/+)

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