SAM (senescence accelerated mice) inbred mice


Characteristics / Husbandry

  • Accelerated aging
  • Coat: Albino
  • Litter Average 5.6
  • Medium survival 12.1 months
Research Use & Related Publications
Geriatric pathogenesis
Senile amyloidosis (apolipoprotein A-II)
Hearing impairment
Emotional disorders
Aging process
Age-dependent disorders
Senile osteoporosis
Hyperinflation of the lungs
Deficits in learning and memory
Brain atrophy
Accelerated senescence studies
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SAM models were developed from AKR/J by Kyoto University. Five litters with severe senescence were selected to further propagate and examine these characteristics. Litters that showed normal aging were selected as a senescence-resistant series (R-series). The genetic background of the SAM mice became suspect after the pathological findings were different from the AKR/J mouse. Each SAM model is genetically different. Each SAM colony was acquired by Harlan from Takeda Chemical Ltd. in 2002. Harlan became Envigo in 2015.

Order Code: 956

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