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FVB inbred mice

LOCATION

Characteristics / Husbandry

  • Coat: Albino
  • Haplotype: H-2q
  • Litter average: 8.5
  • Swiss background mouse with good reproductive characteristics
  • Fertilized eggs contain large and prominant pronuclei
  • Impaired vision due to the homozygosity of the recessive rd (retinal degeneration) mutation
Research Use & Related Publications
Transgenic model development
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Outbred N:Gp (NIH General-purpose) Swiss mice, established at the National Institutes of Health, Bethesda, Maryland, USA in 1935. In 1966 two strains (HSFS/N and HSFR/N) were selected for sensitivity and resistance, respectively, to the action of Histamine after treatment with Bordetella pertussis vaccination. In the early 1970’s, a group of mice at the eighth inbred generation of HSFS/N were found to carry the Fv-1b, allele for sensitivity to the B strain of Friend leukaemia virus. Homozygous mice were then inbred as strain FVB, without further selection for histamine sensitivity (Taketo et al, 1991).

Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland, in 1988.

Order Code: 118

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