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C57BL/6 aged inbred mice

LOCATIONS

Characteristics / Husbandry

  • Coat: Black
  • Haplotype: H-2b
  • High preference for alcohol
  • Incidence of hydrocephalous
  • Litter average: 6.0
  • Low tumor incidence
  • Microphthalmia
  • Most widely-used inbred strain
  • The C57BL/6JRccHsd subline does not carry the Nnt (nicotinamide nucleotice transhydrogenase) gene deletion

Common age-associated conditions include:

  • Hair loss
  • Loss of motor skills and sensory perception
  • Presence of spontaneous tumors
  • Reduced immunologic and physiologic function
  • Loss of vision, e.g. retinal degeneration, development of cataracts
Research Use & Related Publications
Metabolism
Cardiovascular
Memory
Osteoarthritis
Neoplasia
Immune response
Longevity
Vision and hearing
Motor skills
Renal degeneration
Age-associated pathology
Neurobiology
Reproductive senescence
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The C57BL/JRccHsd mice originate from Jackson Laboratory, Bar Harbor, Maine and were moved in 1973 to RCC Ltd. (formerly Ibm and BRL) in Füllinsdorf, Switzerland. To Harlan Laboratories through acquisition in 2004. Harlan became Envigo in 2015.

Order Code: 043

Technical resources


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