Juvenile toxicology

You are initiating a toxicology and safety assessment program for your product and need to conduct a juvenile toxicity study. Where do you begin?  How do you know when to conduct a general toxicity study versus more complex study designs with target organ and toxicokinetic evaluations? Envigo is here for you.  Our testing facilities have the requisite expertise, training and experience to design, conduct, interpret and report juvenile toxicity studies that will meet your specific objectives and regulatory agencies requirements. 

At Envigo we offer the following expertise and capabilities for your study:

  • Selection of a model:  Typically toxicity studies are performed on the sprague dawley rat, although Envigo can adapt the study for mice, rabbits, minipigs, dogs, or cynomolgus monkeys
  • Selection of an appropriate age range for test animals based on the intended pediatric population
  • Selection of dose levels based on regulatory requirements
  • Selection of route of administration
  • Selection of sample size and logistical planning
  • Laboratory technical expertise including cross fostering litters, toxicokinetics, hematology and clinical chemistry blood sampling techniques, immunological/behavioral/reproductive assessments, and specialized necropsy techniques 

Envigo’s team supporting you comprises experts across multiple areas:

  • Resource management
  • Reproductive and behavioral technical personnel
  • Pharmacists
  • Sample logistics personnel
  • Bioanalytical specialists
  • Inhalation specialists
  • Necropsy technicians
  • Histologists
  • Clinical pathologists
  • Immunologists
  • Anatomic pathologists [including neurohistopathologists]
  • Toxicokineticists
  • Statisticians
  • Quality assurance auditors
  • Report production personnel
  • Institutional animal care and use committee members 

At Envigo, numerous juvenile toxicity studies have been performed over many years and our scientific and technical expertise, as well as extensive historical control data, is recognized worldwide. How can we help you? 

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