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Envigo offers a large collection of pre-developed genetically engineered neurological rat models including advanced disease research rat models including Parkinson’s, Alzheimers, and autism to name a few. Envigo is a leader in molecular and phenotypic services featuring extensive scientific expertise in customized study and assay design, numerous in life and end point measurements, and study flexibility with comprehensive scientific project management.

We are consistently and reliably available to partner with you on a scientific and personal level to design, execute, and deliver exactly what you need to achieve and exceed your research and development goals.

 

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Genetically engineered models (GEMs)

Rat Model Specific Disease/Biological Function Therapeutic Area
5Ht3a-Cre Cre Tool for conditional expession or deletion in 5HT3a+ neurons Neuroscience, Optogenetics
Alpha-Synuclein A53T SNCA KI
Alpha-Synuclein SNCA KO
Parkinson's disease Neuroscience
ApoE KO Alzheimer's disease Neuroscience, Cardiovascular
App KO Alzheimer's disease Neuroscience
Bcrp KO Drug metabolism, Transporter ADMET, Neuroscience
BDNF KO Alzheimer's disease, Schizophrenia, Huntington's disease Neuroscience
Cacna1c KO Autism (ASD) Neuroscience
CamKIIa-Cre Cre Tool for conditional expession or deletion in CamKIIa+ neurons Neuroscience, Optogenetics
CHD8 KO Autism (ASD) Neuroscience
Chrna7 KO Epilepsy, Schizophrenia Neuroscience
Cntnap2 KO Autism (ASD) Neuroscience
Disc1 KO Schizophrenia Neuroscience
Dopamine Transporter (DAT)-Cre Cre Tool for conditional expession or deletion in dopaminergic neurons Neuroscience, Optogenetics
Faah KO Pain Neuroscience
Fmr1 KO Autism (ASD), Fragile X syndrome Neuroscience
Gabrb3 Autism (ASD), Epilepsy, Prader-Willi Neuroscience
hApoe2 Knock-In
hApoe3 Knock-In
hApoE4 Knock-In
Alzheimer's disease Neuroscience
Lrrk1 KO
Lrrk1-Lrrk2 KO
Lrrk2 KO
Parkinson's disease Neuroscience
MeCP2 KO Autism (ASD), Rett Syndrome Neuroscience
Met KO Autism (ASD) Neuroscience
mGluR5 KO Autism (ASD), Fragile X syndrome, Schizophrenia Neuroscience
Neurexin1 (Nrxn1) KO Autism (ASD), Schizophrenia Neuroscience
Neuroligin 3 (Nlgn3) KO Asperger's syndrome, Autism (ASD) Neuroscience
Oprm1 KO
p75NTR KO
Pain Neuroscience
Park2 Parkin KO
Park7 DJ-1 KO
Parkinson's disease Neuroscience
Pde4b KO Bipolar disorder, Schizophrenia Neuroscience
Pink1 Park6 KO Parkinson's disease Neuroscience
Pten KO Autism (ASD), Oncology Neuroscience, Oncology
Rbfox1 KO Autism (ASD) Neuroscience
Sst-Cre Cre Tool for conditional expession or deletion in SST+ neurons Neuroscience, Optogenetics
tdTomato Reporter Optogenetics Neuroscience
Tph2-Cre Cre Tool for conditional expession or deletion in Tph2+ neurons Neuroscience, Optogenetics
Trpv1 KO Pain Neuroscience
TH-Cre
Vgat-Cre
VIP-Cre
Cre Tool for conditional expession or deletion in Th+ neurons Neuroscience, Optogenetics
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