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    Envigo offers a large collection of pre-developed genetically engineered neurological rat models including advanced disease research rat models including Parkinson’s, Alzheimers, and autism to name a few. Envigo is a leader in molecular and phenotypic services featuring extensive scientific expertise in customized study and assay design, numerous in life and end point measurements, and study flexibility with comprehensive scientific project management.

    We are consistently and reliably available to partner with you on a scientific and personal level to design, execute, and deliver exactly what you need to achieve and exceed your research and development goals.

     

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    Genetically engineered models (GEMs)

    Rat Model Specific Disease/Biological Function Therapeutic Area
    5Ht3a-Cre Cre Tool for conditional expession or deletion in 5HT3a+ neurons Neuroscience, Optogenetics
    Alpha-Synuclein A53T SNCA KI
    Alpha-Synuclein SNCA KO
    Parkinson's disease Neuroscience
    ApoE KO Alzheimer's disease Neuroscience, Cardiovascular
    App KO Alzheimer's disease Neuroscience
    Bcrp KO Drug metabolism, Transporter ADMET, Neuroscience
    BDNF KO Alzheimer's disease, Schizophrenia, Huntington's disease Neuroscience
    Cacna1c KO Autism (ASD) Neuroscience
    CamKIIa-Cre Cre Tool for conditional expession or deletion in CamKIIa+ neurons Neuroscience, Optogenetics
    CHD8 KO Autism (ASD) Neuroscience
    Chrna7 KO Epilepsy, Schizophrenia Neuroscience
    Cntnap2 KO Autism (ASD) Neuroscience
    Disc1 KO Schizophrenia Neuroscience
    Dopamine Transporter (DAT)-Cre Cre Tool for conditional expession or deletion in dopaminergic neurons Neuroscience, Optogenetics
    Faah KO Pain Neuroscience
    Fmr1 KO Autism (ASD), Fragile X syndrome Neuroscience
    Gabrb3 Autism (ASD), Epilepsy, Prader-Willi Neuroscience
    hApoe2 Knock-In
    hApoe3 Knock-In
    hApoE4 Knock-In
    Alzheimer's disease Neuroscience
    Lrrk1 KO
    Lrrk1-Lrrk2 KO
    Lrrk2 KO
    Parkinson's disease Neuroscience
    MeCP2 KO Autism (ASD), Rett Syndrome Neuroscience
    Met KO Autism (ASD) Neuroscience
    mGluR5 KO Autism (ASD), Fragile X syndrome, Schizophrenia Neuroscience
    Neurexin1 (Nrxn1) KO Autism (ASD), Schizophrenia Neuroscience
    Neuroligin 3 (Nlgn3) KO Asperger's syndrome, Autism (ASD) Neuroscience
    Oprm1 KO
    p75NTR KO
    Pain Neuroscience
    Park2 Parkin KO
    Park7 DJ-1 KO
    Parkinson's disease Neuroscience
    Pde4b KO Bipolar disorder, Schizophrenia Neuroscience
    Pink1 Park6 KO Parkinson's disease Neuroscience
    Pten KO Autism (ASD), Oncology Neuroscience, Oncology
    Rbfox1 KO Autism (ASD) Neuroscience
    Sst-Cre Cre Tool for conditional expession or deletion in SST+ neurons Neuroscience, Optogenetics
    tdTomato Reporter Optogenetics Neuroscience
    Tph2-Cre Cre Tool for conditional expession or deletion in Tph2+ neurons Neuroscience, Optogenetics
    Trpv1 KO Pain Neuroscience
    TH-Cre
    Vgat-Cre
    VIP-Cre
    Cre Tool for conditional expession or deletion in Th+ neurons Neuroscience, Optogenetics
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