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Download white paperWhat comes out of your research depends in large part on what goes into your research models. Ensuring your study animals have the most appropriate diet is critical to maintaining consistent, reliable research data.
The sodium content of natural ingredients such as corn, wheat, and soybean meal is low. Thus, these ingredients can be used to create a base diet that is sodium deficient. To this base diet, various amounts of sodium chloride salt (NaCl) can be added, and other ingredients adjusted slightly to maintain a relatively constant nutrient profile (with the exception of sodium and chloride).
Below are examples from a popular series of adjusted NaCl diets. Contact us for more information.
Formula examples | |||||
---|---|---|---|---|---|
Added NaCl (%) | Approx. Na (%) | no dye | red* dye | orange* dye | blue* dye |
Na deficient | 0.01-0.02 | TD.90228 | TD.08290 | ||
Possible control diets: 0.05% Na (0.1% NaCl) meets est. minimum Na requirement. Typical rodent diets contain 0.2%-0.4% Na (~0.5-1% NaCl). | |||||
0.1 | 0.05 | TD.94268 | TD.07334 | ||
0.49 | 0.2 | TD.96208 | TD.110765 | ||
1 | 0.4 | TD.90229 | |||
Diets for studies that look at effects of excess sodium consumption in rodents. | |||||
2 | 0.8 | TD.95078 | TD.130345 | ||
4 | 1.6 | TD.92034 | TD.110078 | TD.03095 | |
8 | 3.2 | TD.92012 | TD.03142 |
* When added to natural ingredient diets, these water soluble food dyes offer a slight color tint. More intense color can be achieved at higher inclusion rates.
Ask a nutritionist about additional salt concentrations or color options.
These diets are grain-based, with no animal derived ingredients, and have a background sodium content of approx. 0.01-0.02% and a background chloride content of approx. 0.06-0.07%. The selected nutrient content of the diets are as follows: approximately 19% protein, 5% fat, 3% crude fiber, 0.86% Ca, 0.64% P, 0.72% K, and 0.15% Mg.
NaCl adjusted diets are often fed to dahl salt-sensitive/resistant (rapp) inbred rats. These rats are maintained on Teklad traditional diet 7034 (0.12% NaCl) within maximum security production facilities.
For additional formulas of this nature, or for a purified sodium adjusted diet, please email us at askanutritionist@envigo.com.
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