B-NDG knockout mice: NOD.CB17-Prkdcscid IL2rgem1/BcgenHsd GEM mice

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B-NDG knockout mice

NOD.CB17-Prkdc^scid IL2rg^tm1/BcgenHsd

Strain

NOD.CB17-Prkdc^scid IL2rg^tm1/BcgenHsd

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Strain

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Order code: 126

select features

Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16
Coat: Albino
Common gamma chain gene (II2rg) interrupted
Deficiency in cytokine signaling
Deficient in T and B cells
High humanization capability
Lacks functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21
Lacks NK cells
Severe lymphocyte development impairment

Origin:

The B-NDG model is a single knockout mouse with an ultra immunodeficient phenotype. The model was generated by Biocytogen by deleting the IL2rg gene from NOD-scid mice.

Prkdc (protein kinase DNA-activated catalytic) null scid mutation is characterized by significantly deficient of functional T cells and B cells.

The Common gamma chain gene (IL2RG) deletion results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, which results in the lack of functional NK cells.

Envigo licensed the mouse model from Biocytogen in 2019, where the model had been maintained. The model is albino.

United States - 282I - Indianapolis, IN

Download growth curve

growth-curve-nod-cb17-prkdcscid-il2rgtm1-bcgenhsd

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

I. For-Profit (Commercial) Female Order code: 126 - US

Description	Price	Currency
3-4 weeks	210.00	USD
4-5 weeks	210.00	USD
5-6 weeks	210.00	USD
6-7 weeks	211.00	USD
7-8 weeks	212.00	USD
8-9 weeks	214.00	USD
9-10 weeks	215.00	USD
Over 10 weeks, add/week	5.00	USD

I. For-Profit (Commercial) Male Order code: 126 - US

Description	Price	Currency
3-4 weeks	170.00	USD
4-5 weeks	170.00	USD
5-6 weeks	170.00	USD
6-7 weeks	171.00	USD
7-8 weeks	172.00	USD
8-9 weeks	174.00	USD
9-10 weeks	175.00	USD
Over 10 weeks, add/week	5.00	USD

II. Non-Profit (Academic) Female Order code: 126 - US

Description	Price	Currency
3-4 weeks	100.00	USD
4-5 weeks	100.00	USD
5-6 weeks	100.00	USD
6-7 weeks	100.00	USD
7-8 weeks	100.00	USD
8-9 weeks	105.00	USD
9-10 weeks	109.00	USD
Over 10 weeks, add/week	5.00	USD

II. Non-Profit (Academic) Male Order code: 126 - US

Description	Price	Currency
3-4 weeks	78.00	USD
4-5 weeks	78.00	USD
5-6 weeks	78.00	USD
6-7 weeks	78.00	USD
7-8 weeks	78.00	USD
8-9 weeks	83.00	USD
9-10 weeks	88.00	USD
Over 10 weeks, add/week	5.00	USD

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