Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

• Background strain: Sprague Dawley
• Homozygous knockout rats exhibit complete loss of Trpv1 protein
• Trpv1 knockout rats show hyposensitivity to thermal pain via hot plate assay

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

This model contains a biallelic deletion of the Trpv1 gene, encoding for the transient receptor potential cation channel subfamily V member 1. Capsaicin, the component in chili peppers that makes them hot, is an exogenous ligand for Trpv1. Trpv1 is also activated by heat.

Trpv1 is a non-selective cation channel, activated by a range of stimuli including capsaicin, cannabinoids, and heat.  Trpv1 activation results in the sensation of pain as well as the lowering of body temperature.  Trpv1 antagonists are being pursued as potential novel analgesics.