Rag2 knockout rats Sprague Dawley: HsdSage:SD-Rag2em1sage GEM rats

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Rag2 knockout rats (Sprague Dawley)

HsdSage:SD-Rag2^em1sage

Strain

HsdSage:SD-Rag2^em1sage

Location

U.S.

Strain

Location

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select features

2 bp deletion within Exon 3 on chromosome 3
Homozygous Rag2 knockout rats display loss of RAG2 protein via Western blot
Homozygous Rag2 knockout rats show loss of B and T cells by FACS analysis

Availability: Live colony
Zygosity genotype: Homozygous

Rag2 knockout rats completely lack B and T cells, making them ideal immuno-compromised hosts for xenograft studies. In addition, the larger size of the rat makes performing sophisticated xenograft techniques and surgeries much simpler as compared to similar studies in a mouse.

Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag2 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, autoimmune and infectious diseases.

Origin:

The Rag2 (Sprague-Dawley^®) KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

United States - Room 12 - Boyertown

Rag2_figure2-01

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Model information sheet

Research use and related publications

Infectious disease
Oncology
Vaccines
Cancer metastasis
Immunology
Inflammation/Autoimmune disorders
Hematopoieses
Thrombosis/Cardiac fibrosis
Vascular defects
Xenograft

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