Pten knockout rats: HsdSage:SD-Ptentm1Sage GEM rats

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Pten knockout rats

HsdSage:SD-Pten^tm1Sage

Strain

HsdSage:SD-Pten^tm1Sage

Location

Strain

Location

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This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization by Dr. Richard Paylor at Baylor College of Medicine
Mutations in Pten have been associated with autism
Background Strain: Sprague-Dawley

Availability: Cryopreserved as a mix of Heterozygous & WT embryos
Zygosity: Heterozygous

This model contains a monoallelic deletion of the phosphatase and tensin homolog gene (Pten). Pten mutations have been linked with autism, making this model useful for the study of autism spectrum disorders.

Origin:

The Pten Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

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Research use and related publications

Autism
Cancer