Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as a mix of Heterozygous & WT embryos
This model contains a monoallelic deletion of the phosphatase and tensin homolog gene (Pten). Pten mutations have been linked with autism, making this model useful for the study of autism spectrum disorders.
The Pten Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.