Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as heterozygous embryos
This model is a biallelic deletion of the Pde4b gene that regulates and mediates cellular responses to stimuli such as hormones and neurotransmitters. This model will be useful in the study of schizophrenia and bipolar disorder.
The Pde4b Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.