Met knockout rats: HsdSage:SD-Metem1Sage GEM rats

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Met knockout rats

HsdSage:SD-Met^em1Sage

Strain

HsdSage:SD-Met^em1Sage

Location

U.S. (Cryopreserved)

Strain

Location

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Cryopreserved as heterozygous embryos

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

This model possesses a 17 base pair deletion in exon 8 of MET
This model is provided as a heterozygous knockout; homozygous knockout of MET is not viable
Background Strain: Sprague-Dawley

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

Generated in partnership with Autism Speaks, this model possesses a deletion in exon 8 of MET receptor tyrosine kinase (MET). Mutations in MET have been associated with the autism spectrum disorders in human patients, and this model is useful for the study of autism.

Homozygous knockout of MET is embryonic lethal.

Origin:

The Met Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Model information sheet

Research use and related publications

Autism (ASD)
Autoimmune disorders
Neuroscience
Synaptic Plasticity

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