Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

• Homozygous knockout rats exhibit complete loss of protein
• FAAH KO rats show an increased fear/startle reaction as observed in a functional observational battery (Irwin)
• FAAH KO rats show normal sensitivity to thermal pain via hot plate assay
• Background Strain: Sprague Dawley

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

This model contains a biallelic disruption of the Faah gene encoding the fatty acid amide hydrolase. FAAH is a serine hydrolase responsible for the breakdown of endocannabinoids. This model is useful for the study of cannabinoid biology including nociception.

Cannabinoids perform a variety of functions including the regulation of nociception. FAAH KO rats lack the enzyme responsible for endocannabinoid degradation,and endocannabinod levels should be elevated in this model.