Cntnap2 knockout rats: HsdSage:SD-Cntnap2em1Sage GEM rats

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Cntnap2 knockout rats

HsdSage:SD-Cntnap2^em1Sage

Strain

HsdSage:SD-Cntnap2^em1Sage

Location

U.S. (Cryopreserved)

Strain

Location

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Cryopreserved as heterozygous embryos

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

5 base pair deletion in exon 6 of Cntnap2
Background strain: Sprague Dawley
Homozygous knockout rats display total loss of protein via Western blot
Spontaneous seizures >7 weeks of age
This model was created in collaboration with Autism Speaks and underwent phenotypic characterization by Dr. Richard Paylor.

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

Generated in conjunction with Autism Speaks, this model possesses a bi-allelic deletion in the contactin associated protein-like 2 (Cntnap2) gene. A member of the neurexin family, Cntnap2 has been associated with the autism spectrum disorders.

Spontaneous seizures have been observed in homozygous animals >7 weeks of age.

Origin: The Cntnap2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Model information sheet

Research use and related publications

Autism
Neuroscience
Cell adhesion
Language disorders
Synaptic Plasticity

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