Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as heterozygous embryos
Generated in conjunction with Autism Speaks, this model possesses a bi-allelic deletion in the contactin associated protein-like 2 (Cntnap2) gene. A member of the neurexin family, Cntnap2 has been associated with the autism spectrum disorders.
Spontaneous seizures have been observed in homozygous animals >7 weeks of age.