Availability: Live colony
Zygosity genotype: Homozygous
Bcrp plays a protective role in neurotoxicity by limiting the efflux of xenobiotics into the brain. Homozygous null rats demonstrate increased exposure in the brain and plasma when dosed with Bcrp-specific substrates.
Loss of function of Bcrp leads to improper transport of drugs across epithelial cells and increased bioavailability of Bcrp substrates. This model is useful for studying metabolism of xenobiotic compounds, tissue distribution, DMPK, efficacy, formulation, and blood brain barrier efflux.