Availability: Live colony
Zygosity genotype: Homozygous
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson's disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson's disease.
This model is being developed in partner with the Michael J. Fox Foundation as part of our Parkinson's disease research suite. Pink1 protein kinase localizes to the mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations within this gene result in one form of autosomal recessive early-onset Parkinson's.
The Pink1 (Park6) KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.