5Ht3a-Cre knockin rats: HsdSage:LE-5HT3aem1(T2A-Cre)Sage GEM rats

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5Ht3a-Cre knockin rats

HsdSage:LE-5HT3a^{em1(T2A-Cre)Sage}

Strain

HsdSage:LE-5HT3a^{em1(T2A-Cre)Sage}

Location

U.S. (Cryopreserved)

Strain

Location

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Cryopreserved as heterozygous embryos

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background strain: Long Evans Hooded
Cre recombinase driven by endogenous 5Ht3a promoter
No observed ectopic expression of cre
Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC

Availability: Cryopreserved as homozygous embryos
Zygosity genotype: Homozygous

This model expresses cre-recombinase under the control of the endogenous 5’- hydroxytryptamine receptor 3A (5Ht3a) promoter enabling specific expression in 5Ht3a positive serotonergic neurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the 5Ht3a gene. The 5Ht3a-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.

Origin: The 5Ht3a-Cre KI rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Model information sheet

Research use and related publications

Cre Tool for conditional expression or deletion in 5HT3a+ neurons
Expression/knockout of floxed genes
Neuroscience
Optogenetics

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