Rag1 knockout rats (Fischer 344): F344-Rag1em1Sage/SageHsd GEM rats

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Rag1 knockout rats (Fischer 344)

F344-Rag1^em1Sage/SageHsd

Strain

F344-Rag1^em1Sage/SageHsd

Location

U.S. (Cryopreserved)

Strain

Location

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Cryopreserved as heterozygous embryos

Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.

Background Strain: Fischer 344

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes.

Mature B and T cells are critical components for an adaptive immune system. Rats deficient in Rag1 protein produce no mature B or T cells. This non-leaky model for severe combined immune deficiency is useful for vaccine development, as well as the study of autoimmune and infectious diseases.

Origin:

The Rag1 Knockout Rat (Fischer 344) model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo.

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

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Research use and related publications

Cancer metastasis
Immunology
Inflammation/Autoimmune disorders
Oncology
Thrombosis/Cardiac fibrosis
Vaccine development
Xenograft

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