Diabetic (db/db) mice: BKS.Cg-+Leprdb/+Leprdb/OlaHsd mutant mice

Find research models

Diabetic (db/db) mice

BKS.Cg-+Lepr^db/+Lepr^db/OlaHsd

Strain

BKS.Cg-+Lepr^db/+Lepr^db/OlaHsd

Location

The Netherlands

Strain

Location

Order today

+31 (0) 478-578320

Online ordering

select features

Coat: Black or misty
Elevation of plasma insulin demonstrated at 10-14 days
Glycosuria
Hyperglycemia develops at 4-8 weeks of age
Hyperinsulinemia despite severe depletion of pancreatic islet insulin-producing B-cells
Lepr^db is an autosomal-recessive mutation on chromosome 4
Leptin receptor deficient
Obesity expressed at 4-5 weeks of age
Polyphagia
Polyuria/Polydipsia
Proteinuria

Origin:

Reaching your goals in diabetes and obesity studies can be a challenge or a success depending on the reliability of your research models. The Lepr^db mutation was discovered in 1966 in the inbred BKS mouse strain. This model has since been well characterized as a model of Type 2 diabetes mellitus, exhibiting commonly published metabolic symptoms including hyperglycemia and hyperinsulinemia.

From Dunn Nutritional Laboratory, Cambridge, United Kingdom; to Olac, United Kingdom, in 1979; to Harlan, United States in 2000. Harlan became Envigo in 2015.

Our breeding scheme maintains Dock7m and Leprdb in repulsion. These genes are closely linked; however, recombination could occur. Our mice are most likely nonrecombinants, but they have not been tested.

The Netherlands - Barrier 2

Download growth curve

growth-curve-bks-dbdb-males_b2_2016

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

For pricing please contact us using the phone number above

Research use and related publications

Immunology
General studies
Metabolism
Obesity
Diabetes Type 2
Myocardian Disease
Peripheral neuropathy
Immunodeficiency