Diabetic (db/db) mice: BKS.Cg-+Leprdb/+Leprdb/OlaHsd mutant mice

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Diabetic (db/db) mice

BKS.Cg-+Lepr^db/+Lepr^db/OlaHsd

Strain

BKS.Cg-+Lepr^db/+Lepr^db/OlaHsd

Locations

U.S.

The Netherlands

Strain

Locations

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Order code: 173

select features

Coat: Black or misty
Elevation of plasma insulin demonstrated at 10-14 days
Glycosuria
Hyperglycemia develops at 4-8 weeks of age
Hyperinsulinemia despite severe depletion of pancreatic islet insulin-producing B-cells
Lepr^db is an autosomal-recessive mutation on chromosome 4
Leptin receptor deficient
Obesity expressed at 4-5 weeks of age
Polyphagia
Polyuria/Polydipsia
Proteinuria

Origin:

Reaching your goals in diabetes and obesity studies can be a challenge or a success depending on the reliability of your research models. The Lepr^db mutation was discovered in 1966 in the inbred BKS mouse strain. This model has since been well characterized as a model of Type 2 diabetes mellitus, exhibiting commonly published metabolic symptoms including hyperglycemia and hyperinsulinemia.

From Dunn Nutritional Laboratory, Cambridge, United Kingdom; to Olac, United Kingdom, in 1979; to Harlan, United States in 2000. Harlan became Envigo in 2015.

Our breeding scheme maintains Dock7m and Leprdb in repulsion. These genes are closely linked; however, recombination could occur. Our mice are most likely nonrecombinants, but they have not been tested.

United States - 266 - Greenfield, IN

Download growth curve

dbdb-fatty_lean-gc-sept2015

Available regions:

Asia-Pacific Austria Baltic states Belgium East Europe France Germany Ireland Italy Portugal Scandinavia Spain Switzerland The Netherlands United States United Kingdom Other regions

db/db Order code: 173 - US

Description	Price	Currency
3-4 weeks	199.95	USD
4-5 weeks	199.95	USD
5-6 weeks	202.35	USD
6-7 weeks	204.70	USD
7-8 weeks	207.10	USD
Over 8 weeks, add per week	7.25	USD
Retired breeder	216.60	USD

lean Order code: 174 - US

Description	Price	Currency
3-4 weeks	133.95	USD
4-5 weeks	133.95	USD
5-6 weeks	136.90	USD
6-7 weeks	140.45	USD
7-8 weeks	143.60	USD
Over 8 weeks, add per week	5.15	USD
Retired breeder	114.25	USD

Research use and related publications

Diabetes Type 2
General studies
Immunology
Metabolism
Myocardian Disease
Obesity
Immunodeficiency
Peripheral neuropathy

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